2457-81-0

Basic information

• Product Name: 2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol
• Synonyms: 1,3-Indandione,2,2'-nitrilodi- (6CI,7CI,8CI); Protonated Ruhemann's purple
• CAS NO: 2457-81-0
• Molecular Formula: C₁₈H₉NO₄
• Molecular Weight: 303.27
• Mol File: 2457-81-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 642.7°Cat760mmHg
• Flash Point: 342.5°C
• Appearance: /
• Density: 1.85g/cm³
• Vapor Pressure: 2.13E-17mmHg at 25°C
• Refractive Index: 1.843
• CAS DataBase Reference: 2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol(2457-81-0)
• EPA Substance Registry System: 2-(6-aminopurin-9-yl)-5-(methylsulfanylmethyl)oxolane-3,4-diol(2457-81-0)

Safety Data

• Hazardous Substances Data: 2457-81-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7+,8-,11-/m1/s1

Upstream product

• 485-47-2 indan-1,2,3-trione hydrate 
• 302-72-7 rac-Ala-OH 
• 13167-95-8 1H-indene-1,2,3-trione 2-oxime 

Downstream Products

• 104733-11-1 2,4-bis(2',2'-spiro-1',3'-dioxoindanyl)-7-phenyl-6,8-dioxo-cis-3,7-diazabicyclo<3.3.0>octane 

Relevant articles and documents

Utility of chromogenic property of 2, 2-dihydroxyindane-1, 3-dione for quantification of Memantine hydrochloride in pure, pharmaceutical preparation and application to uniformity testing

Accurate, simple, sensitive, and fast spectrophotometric assay was applied for the quantification of certain anti-Alzheimer drug namely; Memantine hydrochloride, in its bulk and pharmaceutical preparation. The described assay has been established on the reaction between the primary amino moiety of the cited drug and 2,2-dihydroxyindane-1,3-dione reagent in N,N′-dimethylformamide medium in boiling water bath. Which give Ruhemann's purple color that can be determined at λmax = 595 nm. Beer's law has been obeyed within drug concentration range from 10-120 μg per milliliter. Detection limit and quantitation limit have been 1.6 & 4.9 μg per milliliter respectively. Developed procedure has been validated in agreement with International Conference of Horizon recommendations and applied successfully for detection of cited drug in bulk, pharmaceutical dosage form and content uniformity testing.

Spectrophotometric determination of alendronate sodium in bulk drug and in pharmaceutical formulation

A sensitive, simple, precise and low-cost spectrophotometry method for alendronate sodium (ALD) determination has been proposed. The procedure is based on the reaction of the primary amino group of alendronate sodium with ninhydrin reagent in a boiling water bath in presence of pyridine to yield a bluish-violet product measured at 565 nm. Linear calibration curve was obtained in the range 1-60μg/ mL, with minimum detectability of 0.1μg/mL. The correlation coefficient was 0.9999 (n = 7). The different experimental parameters have been carefully studied. The proposed method has been successfully applied to the analysis of the studied drug in pure form and in commercial tablets. The average percentage recovery (n = 7) was 99.8 ± 0.35. The results were compared statistically with those obtained from a published method as revealed by t- and F- tests.