2457-81-0Relevant academic research and scientific papers
Utility of chromogenic property of 2, 2-dihydroxyindane-1, 3-dione for quantification of Memantine hydrochloride in pure, pharmaceutical preparation and application to uniformity testing
Atia, Noha N.,Marzouq, Mustafa A.,Hassan, Ahmed I.,Eltoukhi, Walid E.
, (2020)
Accurate, simple, sensitive, and fast spectrophotometric assay was applied for the quantification of certain anti-Alzheimer drug namely; Memantine hydrochloride, in its bulk and pharmaceutical preparation. The described assay has been established on the reaction between the primary amino moiety of the cited drug and 2,2-dihydroxyindane-1,3-dione reagent in N,N′-dimethylformamide medium in boiling water bath. Which give Ruhemann's purple color that can be determined at λmax = 595 nm. Beer's law has been obeyed within drug concentration range from 10-120 μg per milliliter. Detection limit and quantitation limit have been 1.6 & 4.9 μg per milliliter respectively. Developed procedure has been validated in agreement with International Conference of Horizon recommendations and applied successfully for detection of cited drug in bulk, pharmaceutical dosage form and content uniformity testing.
Nanoplatforms of Manganese Ferrite Nanoparticles Functionalized with Anti-Inflammatory Drugs
Giannousi, Kleoniki,Koutroumpis, Emmanouil,Georgiadou, Violetta,Karagkounis, Vasilis,Dendrinou-Samara, Catherine
, p. 1895 - 1903 (2019)
Targeted drug delivery by magnetic nanoparticles (MNPs) is at the leading edge of the rapidly developed methods for the diagnosis and treatment of various diseases. Functionalization of nonsteroidal anti-inflammatory drugs (NSAIDs) onto MNP-based platforms constitutes a challenging endeavor, as it is based on the physicochemical characteristics of the final carrier/system. MnFe2O4 MNPs of relatively small size and enhanced magnetization with aminated (AmMNPs) and non-aminated (Non-AmMNPs) surface were prepared solvothermally in the presence of octadecylamine(ODA) through synthetic variations. Three nonsteroidal anti-inflammatory drugs (NSAIDs), acetylsalicylic acid (ASA), mefenamic acid (MEF) and Naproxen (NAP), of different pharmacochemical properties, were used for the loading of the nanoplatforms. In the case of AmMNPs, attachment of the NSAIDs was achieved by direct coupling of carboxylate donors with the NH2 groups via the formation of an amide bond, whereas indirect coupling of the drugs through encapsulation was applied on Non-AmMNPs by taking advantage of the PEGylation approach. FT-IR and UV/Vis data confirmed the distinct drug release behavior, which is attributed to different cross-linking forces depending on the method of functionalization. The biological behavior and anti-inflammatory activity of the MNPs@NSAIDs was evaluated in vitro; AmMNPs@ASA inhibited lipoxygenase (LOX) and protected albumin denaturation with values comparable with those of NSAIDs.
Spectrophotometric determination of alendronate sodium in bulk drug and in pharmaceutical formulation
Alarfaj, Nawal A.,Abd El-Razeq, Sawsan A.,Al-Qahtani, Fatma N.
experimental part, p. 697 - 700 (2012/04/04)
A sensitive, simple, precise and low-cost spectrophotometry method for alendronate sodium (ALD) determination has been proposed. The procedure is based on the reaction of the primary amino group of alendronate sodium with ninhydrin reagent in a boiling water bath in presence of pyridine to yield a bluish-violet product measured at 565 nm. Linear calibration curve was obtained in the range 1-60μg/ mL, with minimum detectability of 0.1μg/mL. The correlation coefficient was 0.9999 (n = 7). The different experimental parameters have been carefully studied. The proposed method has been successfully applied to the analysis of the studied drug in pure form and in commercial tablets. The average percentage recovery (n = 7) was 99.8 ± 0.35. The results were compared statistically with those obtained from a published method as revealed by t- and F- tests.
On Ruhemann's Purple
Wigfield, Donald C.,Buchanan, Gerald W.,Croteau, Stephen M.
, p. 201 - 205 (2007/10/02)
The 1H nmr spectrum previously reported for Ruhemann's Purple is shown to be inconsistent with the accepted structure of this material.The discrepancy with the reported 1H nmr spectrum is shown to be due to the presence of a major impurity, identified as hydrindantin.Spectra (1H nmr, 13C nmr, ir, uv-visible) of Ruhemann's Purple , its protonated analogue DYDA, and other ninhydrin relatives are reported, and structural conclusions are based on these spectral data.
