24573-95-3

Upstream product

• 93-05-0 N,N-diethylaniline 

Downstream Products

• 65245-58-1 C₁₇H₂₂N₆ 
• 65244-50-0 C₁₇H₂₂N₄ 
• 1207268-76-5 2-{3-cyano-4-(4-(1-(4-diethylamino-phenyl)-1H-[1,2,3]triazol-4-yl)phenyl)-5,5-dimethyl-5H-furan-2-ylidene}malononitrile 
• 1263312-87-3 N,N-diethyl-4-(1H-1,2,3-triazol-1-yl)aniline 

Relevant academic research and scientific papers

Syntheses and biological evaluation of 1,2,3-triazole and 1,3,4-oxadiazole derivatives of imatinib

Three novel series of 1,2,3-triazole and 1,3,4-oxadiazole derivatives of imatinib were prepared and evaluated in vitro for their cytostatic effects against a human chronic myeloid leukemia (K562), acute myeloid leukemia (HL60), and human leukemia stem-like cell line (KG1a). The structure-activity relationship was analyzed by determining the inhibitory rate of each imatinib analog. Benzene and piperazine rings were necessary groups in these compounds for maintaining inhibitory activities against the K562 and HL60 cell lines. Introducing a trifluoromethyl group significantly enhanced the potency of the compounds against these two cell lines. Surprisingly, some compounds showed significant inhibitory activities against KG1a cells without inhibiting common leukemia cell lines (K562 and HL60). These findings suggest that these compounds are able to inhibit leukemia stem-like cells.

Fluorogenic compounds converted to fluorophores by photochemical or chemical means and their use in biological systems

Fluorophores derived from photoactivatable azide-pi-acceptor fluorogens or from a thermal reaction of an azide-pi-acceptor fluorogen with an alkene or alkyne are disclosed. Fluorophores derived from a thermal reaction of an alkyne-pi-acceptor fluorogen with an azide are also disclosed. The fluorophores can readily be activated by light and can be used to label a biomolecule and imaged on a single-molecule level in living cells.