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Usage

Uses

Used in Organic Synthesis:
(1S)-1-(4-CHLOROPHENYL)BUT-3-EN-1-AMINE is used as a building block in organic synthesis for the production of various other compounds. Its unique structure allows for the creation of a wide range of chemical entities with potential applications in different fields.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (1S)-1-(4-CHLOROPHENYL)BUT-3-EN-1-AMINE is used as a starting material for the development of new drugs. Its potential in treating neurological and psychiatric disorders makes it a valuable compound for research and development efforts.
Used in Medicinal Applications:
(1S)-1-(4-CHLOROPHENYL)BUT-3-EN-1-AMINE has shown promise in the treatment of certain neurological and psychiatric disorders. While the exact mechanism of action is still under investigation, its potential therapeutic uses are being explored, making it a compound of interest for further research and development in the medical field.

Upstream product

• 143842-98-2 N-trimethylsilyl-4-chlorobenzylidenamine 
• 949020-94-4 methyl N-[1(S)-(4-chlorophenyl)-3-buten-1-yl]-(S)-valinate 
• 949021-01-6 N-[1(S)-(4-chlorophenyl)-3-buten-1-yl]-(S)-valinol 

Downstream Products

• 949021-20-9 (S)-N-[1-(4-chlorophenyl)-3-buten-1-yl]propenamide 
• 1245770-60-8 (S)-N-[1-(4-chlorophenyl)but-3-enyl]benzamide 

Relevant academic research and scientific papers

Asymmetric synthesis of α- And β-amino acids by diastereoselective addition of triorganozincates to N-(tert-butanesulfinyl) imines

The diastereoselective addition of triorganozincates to (R)-N-(tert-butanesulfinyl)imines has been used as a key step to achieve the synthesis of highly enantiomerically enriched N-protected α- and β-amino acids. Desulfinylation of the addition products followed by benzoylation of the nitrogen atom of the obtained primary amines and oxidation of one of the substituents on the carbon atom connected to the nitrogen complete the sequence. Using the same configuration in the sulfinyl chiral auxiliary, α-amino acids with the (R) or the (S) configuration can be prepared by choosing the proper combination of imine and organozincate. α,α- Disubstituted α-amino esters with high enantiomeric purity can also be prepared when α-imino esters are the starting substrates.

Asymmetric synthesis of δ-substituted α,β-unsaturated δ-lactams by ring closing metathesis of enantiomerically pure N-acryloyl-homoallylic amines

(Chemical Equation Presented) Optically pure secondary homoallylic amines, obtained by highly diastereoselective addition of allylmetal reagents to imines derived from chiral amines, were N-dealkylated, and the primary amines were converted to N-acryloyl

Enantioselective Synthesis of Chiral Homoallyl Alcohols and Homoallylamines by Nucleophilic Addition of an Allylboron Reagent Modified by a Polymer-Supported Chiral Ligand

Crosslinked polymer-supported chiral N-sulfonylamino alcohols 5-8 have been prepared by suspension polymerization of enantiopure N-sulfonylamino alcohol monomers 1-4 with styrene and divinylbenzene. Polymer-supported chiral allylboron reagents were prepared from the polymeric chiral ligands. Enantioselective additions of the polymer-supported allylboron reagents to aldehydes and N-(trimethylsilyl)imines have been successfully carried out in the heterogeneous system. The corresponding optically active homoallyl alcohols and homoallylamines were obtained in high yields with high enantioselectivities (up to 95% ee) which are almost the same as those obtained from homogeneous analogues. The polymer-supported chiral ligands used were recovered easily and can be reused without any loss of activity.