245745-97-5

Basic information

• Product Name: 2-chloro-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]nicotinanilide
• Synonyms: 2-chloro-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]nicotinanilide
• CAS NO: 245745-97-5
• Molecular Weight: 434.728
• Mol File: 245745-97-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-chloro-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]nicotinanilide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]nicotinanilide(245745-97-5)
• EPA Substance Registry System: 2-chloro-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]nicotinanilide(245745-97-5)

Safety Data

• Hazardous Substances Data: 245745-97-5(Hazardous Substances Data)

Upstream product

• 56055-55-1 2-chloropyridin-3-carboxylic acid HCl salt 
• 123066-64-8 4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl] aniline 

Downstream Products

• 292610-32-3 2-hydroxy-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]nicotinanilide 

Relevant articles and documents

Novel potent and selective Ca2+ release-activated Ca2+ (CRAC) channel inhibitors. Part 3: Synthesis and CRAC channel inhibitory activity of 4′-[(trifluoromethyl)pyrazol-1-yl]carboxanilides

From a series of 4'-[(trifluoromethyl)pyrazol-1-yl]carboxanilides derived from 4-methyl-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-1,2,3-thiadiazole-5-carboxanilide, one inhibited thapsigargin-induced Ca2+ influx in Jurkat T cells (IC50 = 77 nM) and exhibited high selectivity for the CRAC channel over the VOC channel (index: >130). Another acted as an inhibitor for both T lymphocyte activation-induced diseases and ovalbumin-induced airway eosinophilia in rats (ED50 = 1.3 mg/kg) p.o.