245759-95-9Relevant academic research and scientific papers
COMPOUND HAVING KDM5 INHIBITORY ACTIVITY AND PHARMACEUTICAL USE THEREOF
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Page/Page column 122, (2021/02/12)
The present invention provides KDM5 inhibitor. The compound disclosed herein represented by the general formula (Z): wherein all symbols have the same meanings as the definitions described in the specification; or a salt thereof is useful as a prophylactic and/or therapeutic agent for cancer, Huntington's disease, or Alzheimer's disease and the like.
A facile one-pot synthesis of the very useful building blocks N-boc-S- alkylatedcysteines
Cundari, Sante,Dalpozzo, Renato,De Nino, Antonio,Procopio, Antonio,Sindona, Giovanni,Athanassopulos, Kostantinos
, p. 10155 - 10162 (2007/10/03)
A convenient one-pot method for the synthesis of N-Boc protected S- alkylcysteines, useful intermediates for the solution-phase synthesis of glutathione-conjugates and modified peptides is presented, together with the reactivity of epoxides, halohydrins and α-halo carbonyl derivatives towards the sulfur nucleophile of the substrate. The reactions with α-halo esters lead to thiomorpholinocarboxylic acids which are interesting potential inhibitors of transport systems.
