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245762-27-0

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245762-27-0 Usage

Description

3-(5-Fluoro-1H-indol-3-yl)propylamine is an organic compound with the molecular formula C11H12FN3. It is a derivative of indole, a heterocyclic compound commonly found in nature. 3-(5-FLUORO-1H-INDOL-3-YL)PROPYLAMINE contains a fluorine atom as well as a propylamine group, which makes it a member of the amine family of compounds. This chemical is used in pharmaceutical and research applications, particularly in the development of new drugs and medications. Its specific properties and potential uses are still being researched and explored by scientists and chemists.

Uses

Used in Pharmaceutical Industry:
3-(5-Fluoro-1H-indol-3-yl)propylamine is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and functional groups make it a valuable building block in the development of new drugs and medications.
Used in Research Applications:
3-(5-Fluoro-1H-indol-3-yl)propylamine is used as a research chemical to study its properties and potential applications. Scientists and chemists are exploring its reactivity, stability, and interactions with other molecules to gain insights into its potential uses in various fields.

Check Digit Verification of cas no

The CAS Registry Mumber 245762-27-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,4,5,7,6 and 2 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 245762-27:
(8*2)+(7*4)+(6*5)+(5*7)+(4*6)+(3*2)+(2*2)+(1*7)=150
150 % 10 = 0
So 245762-27-0 is a valid CAS Registry Number.

245762-27-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(5-fluoro-1H-indol-3-yl)propan-1-amine

1.2 Other means of identification

Product number -
Other names 1H-Indole-3-propanamine,5-fluoro

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:245762-27-0 SDS

245762-27-0Relevant articles and documents

3-ALKYL-5-FLUOROINDOLE DERIVATIVES AS MYELOPEROXIDASE INHIBITORS

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Page/Page column 7, (2012/05/21)

The invention relates to a compound of formula (Ia) wherein n is an integer between 2 and 10, R1 and R2 independently represent a substituent selected from the group consisting of hydrogen, C1-C10 alkyl, C3-C10 cycloalkyl and aminoalkyl, or R1 and R2 are taken together with the nitrogen atom to which they are attached to form a four to ten-membered heterocycle, R5 represents independently in each of the n units a substituent selected from the group consisting of hydrogen, C1-C10 alkyl, halogen, alkoxy, aminoalkyl and alkylamino; or a pharmaceutically acceptable salt thereof, with the proviso that the 5-fluorotryptamine is excluded, for the treatment or the prophylaxis of neuroinflammatory diseases or disorders. The invention also relates to a pharmaceutical composition, a method for inhibiting myeloperoxidase enzyme activity, to a method for inhibiting Low density lipoproteins oxidation.

Studies toward the discovery of the next generation of antidepressants. 3. Dual 5-HT1A and serotonin transporter affinity within a class of N-aryloxyethylindolylalkylamines

Mewshaw, Richard E.,Zhou, Dahui,Zhou, Ping,Shi, Xiaojie,Hornby, Geoffrey,Spangler, Taylor,Scerni, Rosemary,Smith, Deborah,Schechter, Lee E.,Andree, Terrance H.

, p. 3823 - 3842 (2007/10/03)

N-Aryloxylethylindolealkylamines (5) having dual 5-HT transporter and 5-HT1A affinity are described. These compounds represent truncated analogues of our previously reported piperidinyl derivatives (3). Compounds in this investigation were found to have more similar affinities and functional activities for the 5-HT1A receptor and 5-HT transporter. Though 5-HT1A antagonism is not consistently observed throughout series 5, several molecular features were found to be essential to obtain high and balanced activities. The proper placement of a heteroatom in the aryl ring and the length of the linkage used to tether the indole moiety had significant influence on 5-HT1A and 5-HT transporter affinities. Introduction of a halogen into the aryl ring usually lowered intrinsic activity and in some cases led to full 5-HT1A antagonists. Compounds 33 and 34 were observed to be full 5-HT1A antagonists with Ki values of approximately 30 nM for the 5-HT1A receptor and Ki values of 5 and 0.5 nM for the 5-HT transporter, respectively. Unfortunately, similar to our previous series (3), compounds in this report also had high affinity for the α1 receptor.

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