24578-06-1Relevant articles and documents
Synthesis and investigation of polyhydroxylated pyrrolidine derivatives as novel chemotypes showing dual activity as glucosidase and aldose reductase inhibitors
Guazzelli, Lorenzo,D'Andrea, Felicia,Sartini, Stefania,Giorgelli, Francesco,Confini, Gianluca,Quattrini, Luca,Piano, Ilaria,Nencetti, Susanna,Orlandini, Elisabetta,Gargini, Claudia,La Motta, Concettina
supporting information, (2019/09/30)
Diabetes is a multi-factorial disorder that should be treated with multi-effective compounds. Here we describe the access to polyhydroxylated pyrrolidines, belonging to the D-gluco and D-galacto series, through aminocyclization reactions of two differenti
A SHORT, VERSATILE APPROACH TO POLYHYDROXYLATED PYRROLIDINES UTILIZING A REDUCTIVE ELIMINATION-REDUCTIVE AMINATION AS A KEY STEP
Bernotas, Ronald C.
, p. 469 - 472 (2007/10/02)
An efficient synthesis of epimeric alpha-vinyl pyrrolidines starting from methyl 4,6-O-benzyliden gluco- and galactopyranosides gave ready access to hydroxylated pyrrolidines.
SYNTHESIS OF 1,4-DIDEOXY-1,4-IMINO-D-GLUCITOL, A GLUCOSIDASE INHIBITOR
Kuszmann, Janos,Kiss, Laszlo
, p. 45 - 54 (2007/10/02)
1,2:5,6-Di-O-isopropylidene-D-glucitol was converted via its 1,4-dimethanesulfonate into the 1-azido-4-methanesulfonate which, after deprotection and treatment with barium hydroxide, afforded a 9:1 mixture of the corresponding 3,4- and 4,5-anhydro derivat