24579-17-7Relevant articles and documents
Multiple UDP-glucuronosyltransferases in human liver microsomes glucuronidate both R- and S-7-hydroxywarfarin into two metabolites
Preston Pugh,Pouncey, Dakota L.,Hartman, Jessica H.,Nshimiyimana, Robert,Desrochers, Linda P.,Goodwin, Thomas E.,Boysen, Gunnar,Miller, Grover P.
, p. 244 - 253 (2014)
The widely used anticoagulant Coumadin (R/S-warfarin) undergoes oxidation by cytochromes P450 into hydroxywarfarins that subsequently become conjugated for excretion in urine. Hydroxywarfarins may modulate warfarin metabolism transcriptionally or through