24582-77-2Relevant academic research and scientific papers
A regioselective and convenient one-pot multicomponent synthesis of 9-amino-3,5-diaryl-4,9-dihydro-5H-[1,2,4]triazolo[5,1-c][1,2,4]triazepine-8-thiol
Moustafa, Amr Hassan,Amer, Amer Anwar
, p. 1102 - 1109 (2017/05/25)
An efficient and environment-friendly procedure for the synthesis of a new series of nitrogen bridge-head [1,2,4]triazolo[5,1-c][1,2,4]triazepine derivatives through one-pot three-component reaction of polyfunctional triazole with aromatic aldehydes and acetophenone derivatives using alcoholic sodium hydroxide solution. The same new products were prepared in classical route through reaction of triazole with the corresponding chalcones under the same conditions.
EGFR/HER-2 inhibitors: Synthesis, biological evaluation and 3D-QSAR analysis of dihydropyridine-containing thiazolinone derivatives
Ren, Yu-Jia,Wang, Zhong-Chang,Zhang, Xin,Qiu, Han-Yue,Wang, Peng-Fei,Gong, Hai-Bin,Jiang, Ai-Qin,Zhu, Hai-Liang
, p. 21445 - 21454 (2015/03/30)
A series of dihydropyridine containing thiazolinone derivatives (4a-4r) have been designed, synthesized and their biological activities evaluated as potential EGFR and HER-2 kinase inhibitors and in tumor cell antiproliferation. The synthesized compounds
Anti-tubercular, antioxidant and in vitro anti-inflammatory activity of some newly synthesized chalcones
Alam, Shadab,Panda, Rakesh,Kachroo, Monica
, p. 440 - 443 (2014/05/06)
A series of chalcones of 4-acetyl pyridines and substituted aryl aldehydes have been synthesized and evaluated for antitubercular, antioxidant and anti-inflammatory activity. The structures of the synthesized compounds have been confirmed by IR, 1/s
Synthesis and biological activities of some new pyrazole derivatives from chalcones
Kachroo, Monica,Yadav, Yadavendra,Devi, Kalpana
, p. 141 - 144 (2019/01/21)
Nitrogen containing heterocyclic detivatives synthesized from chalcones have exhibited anti-inflammatory, antioxidant, antitubercular, antibacterial activities. Therefore an attempt has been made to synthesize chalcones by the reaction of 4-acetylpyridine
Synthesis of 4-pyrido-6-aryl-2-substituted amino pyrimidines as a new class of antimalarial agents
Agarwal, Anu,Srivastava, Kumkum,Puri,Chauhan, Prem M.S.
, p. 6226 - 6232 (2007/10/03)
A series of 2,4,6-trisubstituted pyrimidines were synthesized and evaluated for their in vitro antimalarial activity against Plasmodium falciparum. Of the 18 compounds synthesized, 14 compounds showed MIC in the range of 0.25-2 μg/mL. These compounds are
