24588-60-1Relevant academic research and scientific papers
Bismuth(III) triflate as catalyst in carbonyl-Diels-Alder reaction
Oussaid, Adyl,Garrigues, Bernard
, p. 825 - 832 (2002)
In presence of bismuth(III) triflate, a carbonylated electrophile (ethyl mesoxalate or glyoxylate) and usual diene led selectively (60-100) the hetero carbonyl-Diels-Alder reaction with the ene reaction product. Bi(OTf)3 exhibits strong catalytic activity and reacts under mild conditions.
The carbonyl-Diels-Alder reaction catalyzed by bismuth (III) chloride
Robert, Helene,Garrigues, Bernard,Dubac, Jacques
, p. 1161 - 1164 (1998)
In presence of bismuth (III) chloride, a carbonylated electrophile (ethyl mesoxalate or glyoxylate) and usual diene led selectively (65 to 100%) the hetero carbonyl-Diels-Alder reaction the ene reaction product. BiCl3 exhibits strong catalytic activity and, compared with previous literature, reacts under mild conditions.
ACAT inhibitors derived from hetero-Diels-Alder cycloadducts of thioaldehydes
Wilde, Richard G.,Billheimer, Jeffrey T.,Germain, Sandie J.,Hausner, Elizabeth A.,Meunier, Paul C.,Munzer, Deborah A.,Stoltenborg, Janet K.,Gillies, Peter J.,Burcham, Deborah L.,Huang, Shiew-Mai,Klaczkiewicz, John D.,Ko, Soo S.,Wexler, Ruth R.
, p. 1493 - 1513 (2007/10/03)
Acyl-CoA:cholesterol acyltransferase (ACAT) is the enzyme largely responsible for intracellular cholesteror esterification. A systemic inhibitor of ACAT is believed to be able to slow or even reverse the atherosclerotic process. Towards that goal, a series of cyclic sulfides, derived from the hetero-Diels-Alder reaction of thioaldehydes with 1,3-dienes, and bearing carboxamide substituents, were prepared and evaluated for in vitro (in several tissues and species) and ex vivo ACAT inhibition. Minor changes in subsequent structure were found to have a significant effect in optimization of the biological activity of this series of compounds.
Microwave-assisted carbonyl Diels-Alder and carbonyl-ene reactions supported on graphite
Garrigues, Bernard,Laurent, Regis,Laporte, Christian,Laporterie, Andre,Dubac, Jacques
, p. 743 - 744 (2007/10/03)
"Dry" carbonyl Diels-Alder and carbonyl-ene reactions with microwaves and reactants supported on graphite were dramatically accelerated with respect to homogeneous conditions both involving classical or microwave heating. Although the reactions were carried out in an open reactor, a control of the evaporation of volatile reagents was possible, probably due to their retention or confinement by graphite. VCH Verlagsgesellschaft mbH, 1996.
Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis
-
, (2008/06/13)
The present invention provides compounds of Formula I, STR1 or a pharmaceutically acceptable salt forms thereof, which are inhibitors of acyl-Coenzyme A: cholesterol O-acyltransferase (ACAT), pharmaceutical compositions containing such compounds, processes for the preparation of such compounds, and the use of such compounds as antihypercholesterolemic and/or antiatherosclerotic agents.
