24589-89-7

Basic information

• Product Name: (4-BROMO-2-FORMYLPHENOXY)ACETIC ACID
• Synonyms: (4-BROMO-2-FORMYLPHENOXY)ACETIC ACID;AKOS B005879;2-(4-bromo-2-formylphenoxy)acetic acid;2-(4-bromo-2-methanoyl-phenoxy)ethanoic acid
• CAS NO: 24589-89-7
• Molecular Formula: C₉H₇BrO₄
• Molecular Weight: 259.05
• Mol File: 24589-89-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 413.6 °C at 760 mmHg
• Flash Point: 203.9 °C
• Appearance: /
• Density: 1.699 g/cm³
• Vapor Pressure: 1.4E-07mmHg at 25°C
• Refractive Index: 1.62
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.96±0.10(Predicted)
• CAS DataBase Reference: (4-BROMO-2-FORMYLPHENOXY)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (4-BROMO-2-FORMYLPHENOXY)ACETIC ACID(24589-89-7)
• EPA Substance Registry System: (4-BROMO-2-FORMYLPHENOXY)ACETIC ACID(24589-89-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• HazardClass: IRRITANT
• Hazardous Substances Data: 24589-89-7(Hazardous Substances Data)

Usage

General Description

(4-Bromo-2-formylphenoxy)acetic acid is a chemical compound with the molecular formula C9H7BrO4. It is a derivative of phenoxyacetic acid and contains a bromine atom and a formyl group attached to a phenyl ring. (4-Bromo-2-formylphenoxy)acetic acid is commonly used as a building block in organic synthesis, especially in the preparation of various pharmaceuticals and agrochemicals. Its chemical properties make it suitable for use in the development of novel drugs and in the production of crop protection products. Furthermore, it has potential applications in the fields of materials science and biotechnology. Overall, (4-Bromo-2-formylphenoxy)acetic acid is an important chemical with various industrial and research uses.

InChI:InChI=1/C9H7BrO4/c10-7-1-2-8(6(3-7)4-11)14-5-9(12)13/h1-4H,5H2,(H,12,13)

Upstream product

• 6280-80-4 2-Formylphenoxyacetic acid 
• 24581-99-5 methyl (4-bromo-2-formylphenoxy)acetate 
• 51336-47-1 2-formyl-4-bromophenoxyacetic acid ethyl ester 
• 79-11-8 chloroacetic acid 
• 1761-61-1 5-bromosalicyclaldehyde 
• 90-02-8 salicylaldehyde 
• 79-08-3 bromoacetic acid 

Downstream Products

• 1141894-12-3 C₃₀H₃₅BrN₄O₈ 
• 1141894-10-1 C₂₇H₂₆BrN₅O₆ 
• 1141894-11-2 C₁₄H₁₅BrN₂O₆ 
• 1141894-07-6 C₁₆H₂₀BrNO₅ 
• 1141894-05-4 C₁₅H₁₆BrNO₅ 
• 1141894-08-7 C₁₆H₂₀BrN₅O₇ 
• 1141894-06-5 C₁₉H₁₈BrNO₆ 
• 1141894-09-8 C₂₁H₂₇BrN₂O₆ 
• 1141894-13-4 C₂₃H₂₈BrN₃O₇ 
• 23145-07-5 5-bromobenzofuran 

Relevant articles and documents

Organocatalytic Synthesis of Fused Bicyclic 2,3-Dihydro-1,3,4-oxadiazoles through an Intramolecular Cascade Cyclization

Hydrazone-carboxylic acids undergo intramolecular cyclization in the presence of pivaloyl chloride, iPr2NEt, and catalytic DABCO to form a range of substituted fused tricyclic 2,3-dihydro-1,3,4-oxadiazoles in high yields.

Synthesis, characterization and biological screening of some new aryloxyacetic acid analogs

A novel series of 2-(4-bromo-2-formyl-phenoxy)acetyl amino acid and peptide analogs was synthesized by the coupling of 2-(4-bromo-2-formyl-phenoxy)acetic acid with different amino acid methyl ester hydrochlorides, dipeptide and tripeptide methyl esters using dicyclohexylcarbodiimide as the coupling agent and N-methylmorpholine as the base. Structures of all the newly synthesized compounds were elucidated on basis of IR, NMR and MS spectral data as well as elemental analysis. On pharmacological screening, some peptide derivatives were found to exhibit potent bioac-tivity against gram-negative bacterium Pseudomonas aeruginosa, pathogenic fungus Candida albicans and earthworms Megascoplex konkanensis, Pontoscotex corethruses and Eudrilus sp. Dermatophytes were found to be moderately sensitive towards the newly synthesized analogs. Hydrolyzed peptide derivatives displayed better antimicrobial activity in comparison to corresponding esters.

Synthesis and aldose reductase inhibitory activity of a new series of 5- [[2-(ω-carboxyalkoxy)aryl]methylene]-4-oxo-2-thioxothiazolidine derivatives

A new series of 5-[[2-(ω-carboxyalkoxy)aryl]methylene]-4-oxo-2- thioxothiazolidine derivatives was synthesized and evaluated for their potency as aldose reductase inhibitors (ARIs). Their activities were examined in terms of their inhibitory effect on rat lens aldose reductase in vitro and in terms of the preventive effect on sorbitol accumulation in the sciatic nerve of streptozotocin (STZ)-induced diabetic rats in vivo. Of these compounds, some of the naphthylmethylene thiazolidine derivatives were comparable to Zenarestat in the inhibitory potency in vitro and in vivo. In particular, compound 30 was 1.5 times more potent than Zenarestat in the in vivo activity, and had an adequate potency for clinical development.