246023-99-4

Upstream product

• 89979-13-5 benzyl N-chlorosulfonylcarbamate 
• 40615-39-2 5'-O-(4-4'-dimethoxytrityl)thymidine 
• 100-51-6 benzyl alcohol 

Downstream Products

• 246024-05-5 C₄₇H₅₇N₅O₁₄SSi 
• 246024-01-1 Sulfamic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester 

Relevant academic research and scientific papers

Synthesis of a N-acylsulfamide linked dinucleoside and its incorporation into an oligonucleotide

A N-acylsulfamide linked thymidine dinucleoside was synthesized and incorporated into an oligonucleotide (ON). The interest is in a linkage analog that has a higher pKa relative to a phosphodiester and when incorporated into ONs is capable of helix formation with complementary RNA. The hybridization property of the resultant ON with RNA was shown to result in significant destabilization.