24603-68-7

Basic information

• Product Name: 1,2,4-OXADIAZOLIDINE-3,5-DIONE
• Synonyms: 1,2,4-OXADIAZOLIDINE-3,5-DIONE
• CAS NO: 24603-68-7
• Molecular Formula: C₂H₂N₂O₃
• Molecular Weight: 102.05
• Mol File: 24603-68-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 103-105 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.574g/cm³
• Refractive Index: 1.46
• PKA: 10.08±0.20(Predicted)
• CAS DataBase Reference: 1,2,4-OXADIAZOLIDINE-3,5-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-OXADIAZOLIDINE-3,5-DIONE(24603-68-7)
• EPA Substance Registry System: 1,2,4-OXADIAZOLIDINE-3,5-DIONE(24603-68-7)

Safety Data

• Hazardous Substances Data: 24603-68-7(Hazardous Substances Data)

Usage

General Description

1,2,4-Oxadiazolidine-3,5-dione, also known as carboximide, is a white crystalline compound with the molecular formula C3H2N2O3. It is a heterocyclic compound derived from the oxadiazole ring and is known for its diverse applications in the pharmaceutical and agricultural industries. It is used as an intermediate in the synthesis of various pharmaceuticals, herbicides, and pesticides. In addition, 1,2,4-Oxadiazolidine-3,5-dione has been studied for its potential antimicrobial and anticancer properties, making it a promising candidate for the development of new therapeutic agents. However, it is important to note that this compound should be handled with care due to its potential toxicity and irritant properties.

InChI:InChI=1/C2H2N2O3/c5-1-3-2(6)7-4-1/h(H2,3,4,5,6)

Upstream product

• 24603-67-6 N¹-(ethoxycarbonyl)-N³-hydroxyurea 
• 221393-16-4 5-amino-2,3-dihydro-1,2,4-oxadiazol-3-one 
• 78613-40-8 N-(2-Oxanyl)carbamoyloxy-ethylcarbamat 
• 51991-60-7 3-Benzyloxy-1,2,4-oxadiazol-5(4H)-one 
• 24603-66-5 4-hydroxy-allophanic acid methyl ester 

Downstream Products

• 68373-11-5 Quisqualamine 
• 52809-07-1 quisqualic acid 
• 5302-11-4 2,4-Dimethyl-3,5-dioxo-1,2,4-oxadiazolidin 

Relevant articles and documents

Synthesis method of 1, 2, 4-oxadiazole-3, 5-diketone

The invention relates to a synthesis method of 1, 2, 4-oxadiazole-3, 5-diketone. The method comprises the following steps: placing a reaction mixed solution of a compound 1 and an alkali solution in a reaction system, adding an oxidizing agent, reacting for a period of time, adjusting the pH to be acidic, performing filtering, and recrystallizing a filter cake to obtain a compound 2; and placing the compound 2, an inorganic solvent and an organic solvent in a reaction system, adding nitrite for a reaction, and after the reaction is finished, performing filtering and recrystallization to obtain the target compound 1, 2, 4-oxadiazole-3, 5-diketone. According to the method, the raw materials are few in variety and easy to obtain; reaction conditions are mild; compared with a synthesis method in the literature 2, the provided method has less three-waste emission and fewer steps; and hydroxylamine is used in the literature 2, and the requirement for equipment in industrial production is strict, while the hydroxylamine does not need to be used in the method, the process is simple, and the requirement for the equipment is low.

New investigations on syntheses of 1,2,4-oxadiazolidine-3,5-diones

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