246034-30-0

Basic information

• Product Name: 3-Pyridinecarbonyl chloride, 6-(dimethylamino)- (9CI)
• Synonyms: 3-Pyridinecarbonyl chloride, 6-(dimethylamino)- (9CI)
• CAS NO: 246034-30-0
• Molecular Formula: C8H9ClN2O
• Molecular Weight: 184.62286
• Product Categories: ACIDHALIDE
• Mol File: 246034-30-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Pyridinecarbonyl chloride, 6-(dimethylamino)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarbonyl chloride, 6-(dimethylamino)- (9CI)(246034-30-0)
• EPA Substance Registry System: 3-Pyridinecarbonyl chloride, 6-(dimethylamino)- (9CI)(246034-30-0)

Safety Data

• Hazardous Substances Data: 246034-30-0(Hazardous Substances Data)

Upstream product

• 6311-35-9 6-bromonicotinic acid 
• 82846-28-4 6-(dimethylamino)-3-pyridinecarboxylic acid 

Relevant articles and documents

Synthesis and evaluation of 5-fluoro-2-aryloxazolo[5,4- b ]pyridines as β-amyloid PET ligands and identification of MK-3328

5-Fluoro-2-aryloxazolo[5,4-b]pyridines were synthesized and investigated as potential 18F containing β-amyloid PET ligands. In competition binding assays using human AD brain homogenates, compounds 14b, 16b, and 17b were identified as having favorable potency versus human β-amyloid plaque and were radiolabeled for further evaluation in in vitro binding and in vivo PET imaging experiments. These studies led to the identification of 17b (MK-3328) as a candidate PET ligand for the clinical assessment of β-amyloid plaque load.

Synthesis of N-acetylglucosaminyl and diacetylchitobiosyl amides of heterocyclic carboxylic acids as potential chitinase inhibitors

2-(Dimethylammo)oxazoline-4-carboxylic acids 5 were prepared by condensation of binucleophilic amino acids 4 and O-ethyl-N,N-dimethyhsourea 3. New heterocyclic N-acetylglucosaminyl amides and chitobiosyl amides 8 were obtained by the coupling of tetraacetylglucosamine 6a or heptaacetylchitobiosylamine 6b with acid chlorides of heterocyclic carboxylic acids 2 or 5a and subsequent deacetylation. Based on their substitution patterns, compounds 8 were expected to have inhibitory activity towards chitinases. Enzyme assays showed that glycosyl amides 8 indeed were moderate inhibitors of chitinases, the diacetylchitobiosyl amides 8d-f generally having higher inhibitory activities than the N-acetylglucosaminyl amide derivatives 8a-c. Inhibitory activities depended on the chitinase tested.