24611-43-6

Basic information

• Product Name: Benzoic acid, 2-Mercapto-, hydrazide
• Synonyms: Benzoic acid, 2-Mercapto-, hydrazide
• CAS NO: 24611-43-6
• Molecular Formula: C₇H₈N₂OS
• Molecular Weight: 168.21622
• Mol File: 24611-43-6.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzoic acid, 2-Mercapto-, hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-Mercapto-, hydrazide(24611-43-6)
• EPA Substance Registry System: Benzoic acid, 2-Mercapto-, hydrazide(24611-43-6)

Safety Data

• Hazardous Substances Data: 24611-43-6(Hazardous Substances Data)

Usage

Uses

2-Mercaptobenzoic Acid Hydrazide is an intermediate used in the synthesis of N,N’-Bis(2-mercaptobenzoyl)hydrazide (B481825), which is a selective inhibitor of HIV-1 integrase. Has no other effect on other retroviral targets, including reverse transcriptase, protease, and virus attachement, and exhibits no detectable activity against human topoisomerases I and II at concentrations that effectively inhibit integrase.

Upstream product

• 1677-25-4 2-mercaptobenzoyl chloride 
• 147-93-3 Thiosalicylic acid 
• 4892-02-8 Methyl thiosalicylate 
• 5459-63-2 bis[2-(methoxycarbonyl)phenyl]disulfide 

Downstream Products

• 1384180-66-8 2-(5-anilino-1,3,4-thiadiazol-2-yl)benzenethiol 
• 1266817-13-3 C₁₆H₁₇N₃OS 
• 1266816-94-7 C₂₈H₂₀Br₂N₄O₂S₂ 
• 1266817-07-5 C₁₄H₁₁BrN₂OS 
• 1266816-95-8 C₂₈H₂₂N₄O₂S₂ 
• 1266817-04-2 C₁₄H₁₁N₃O₃S 
• 1266816-98-1 C₃₀H₂₆N₄O₂S₂ 
• 1266817-11-1 C₁₅H₁₄N₂OS 
• 1241474-58-7 C₁₃H₁₈N₂O₆S 
• 1241474-56-5 C₁₃H₁₈N₂O₆S 
• 1241474-55-4 C₁₃H₁₈N₂O₆S 
• 1241474-52-1 C₁₃H₁₈N₂O₅S 

Relevant articles and documents

Copper complex of a thienyl-hydrazone rhodamine derivative is a highly selective colorimetric sensor for pyrophosphate

Detection of pyrophosphate (PPi) can be used to monitor gene replication, transcription, and other forms of enzymatic DNA/RNA synthesis, but it can be difficult to perform in real samples because of the presence of many other biomolecules and buffer components. In this study we prepared a colorimetric probe that could detect PPi specifically and selectively in the presence of cysteine, dithiothreitol (DTT), nucleoside triphosphates, and human serum (containing several biomolecules and amino acids). Among four candidate rhodamine derivatives, we found that the copper complex 1 could detect PPi uniquely, even in the presence of several competing biomolecules. The copper complex 1 also exhibited its highly selective PPi sensing capability when applied to rolling circle amplification and in vitro transcription in samples containing high concentrations of DTT, making it a promising candidate for colorimetric detection of RNA/DNA when using amplification techniques.

Synthesis of some 1,3,4-thiadiazole derivatives as inhibitors of Entamoeba histolytica

In the quest for potent anti-amoebic agents, some 1,3,4-thiadiazole derivatives were synthesized and characterized by spectral data. The purity of the compounds was confirmed by elemental analysis. All the compounds were screened in vitro against HM1:IMSS strain of Entamoeba histolytica by microdilution method. The results revealed that compounds 1 (IC50 = 0.670 μM), 3 (IC50 = 1.60 μM) and 8 (IC50 = 0.522 μM) had much better anti-amoebic activity than the reference drug metronidazole (IC50 = 1.80 μM). Further, cytotoxicity of the compounds having IC50 value less than metronidazole was assessed by MTT assay on human breast cancer MCF-7 cell line and all the compounds were found low cytotoxic in the concentration range of 2.5-250 μM. Preliminary results indicate that these three compounds (1, 3 and 8) may be subjected to further investigations and it may be hoped that the present study will stimulate efforts towards the development of novel effective anti-amoebic agents.

Condensed 1,3-Benzothiazinones. 1. Facile Synthesis of 2-Amino-1,2,4-triazolobenzothiazin-9-one

Treating 2-mercaptobenzohydrazide (1a) with cyanogen bromide gave 3-amino-2-imino-3,4-dihydro-2H-1,3-benzothiazin-4-one (2a).This compound underwent further cyclocondensation with a second molecule of cyanogen bromide or S-methylthiourea sulfate to afford