24617-00-3Relevant academic research and scientific papers
Differential Inhibition of APOBEC3 DNA-Mutator Isozymes by Fluoro- and Non-Fluoro-Substituted 2′-Deoxyzebularine Embedded in Single-Stranded DNA
Kvach, Maksim V.,Barzak, Fareeda M.,Harjes, Stefan,Schares, Henry A. M.,Kurup, Harikrishnan M.,Jones, Katherine F.,Sutton, Lorraine,Donahue, John,D'Aquila, Richard T.,Jameson, Geoffrey B.,Harki, Daniel A.,Krause, Kurt L.,Harjes, Elena,Filichev, Vyacheslav V.
, p. 1028 - 1035 (2020/01/02)
The APOBEC3 (APOBEC3A-H) enzyme family is part of the human innate immune system that restricts pathogens by scrambling pathogenic single-stranded (ss) DNA by deamination of cytosines to produce uracil residues. However, APOBEC3-mediated mutagenesis of vi
Efforts towards expansion of the genetic alphabet: Pyridone and methyl pyridone nucleobases
Leconte, Aaron M.,Matsuda, Shigeo,Hwang, Gil Tae,Romesberg, Floyd E.
, p. 4326 - 4329 (2007/10/03)
(Figure Presented) Getting on with it: A common problem with hydrophobic non-natural base pairs - the inefficient extension following such a base pair - is reduced by using the methylpyridone scaffold, which simultaneously limits another frequent problem
Glycosylations of Ambident Anions of 2(1H)- and 4(1H)-Pyridone and Stereoselective Synthesis of 2(1H)-Pyrimidinone N-(2'-Deoxy-α-D-ribofuranoside)
Seela, Frank,Bindig, Uwe
, p. 895 - 902 (2007/10/02)
Glycosylation of the ambident anions of 2(1H)-pyridone (6) and 4(1H)-pyridone (11) in the presence of KOH with 2-deoxy-3,5-di-O-(p-toluoyl)-α-D-erythro-pentofuranosyl chloride (7) stereoselectively yielded the β-D-O-glycosides 8 and 12, together with anom
