24617-04-7

Upstream product

• 19064-67-6 6-chloro-2H-pyridazin-3-one 
• 4330-21-6 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride 

Relevant academic research and scientific papers

Studies on improved synthesis of 2′-deoxyribonucleosides of pyridazine derivatives

A number of 2′-deoxyribonucleosides of halogenated pyridazine derivatives were prepared by glycosylation of their respective potassium or DBU salts in acetone. The reaction yielded predominatly β-anomers that could be purified by simple crystallization or column chromatography. Of the studied pyridazines and deoxynucleosides, only 4-bromo-6-chloro-pyridazin-3-one and 6-chloro-2-(2′-deoxyribofuranosyl)pyridazin-3-one showed modest inhibition of CK2 kinase.