246236-72-6

Basic information

• Product Name: (2R,3S)-3-Phenyl-oxirane-2-carboxylic acid bis-((S)-1-phenyl-ethyl)-amide
• Synonyms: (2R,3S)-3-Phenyl-oxirane-2-carboxylic acid bis-((S)-1-phenyl-ethyl)-amide
• CAS NO: 246236-72-6
• Molecular Weight: 371.479
• Mol File: 246236-72-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2R,3S)-3-Phenyl-oxirane-2-carboxylic acid bis-((S)-1-phenyl-ethyl)-amide(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-3-Phenyl-oxirane-2-carboxylic acid bis-((S)-1-phenyl-ethyl)-amide(246236-72-6)
• EPA Substance Registry System: (2R,3S)-3-Phenyl-oxirane-2-carboxylic acid bis-((S)-1-phenyl-ethyl)-amide(246236-72-6)

Safety Data

• Hazardous Substances Data: 246236-72-6(Hazardous Substances Data)

Upstream product

• 246236-70-4 (S,S)-(E)-N-cinnamoyl-bis(α-methylbenzyl)amine 
• 102-92-1 Cinnamoyl chloride 
• 21003-56-5 (1S,1'S)-bis(1-phenylethyl)amine 

Downstream Products

• 5411-12-1 trans-(2S,3R)-epoxy-1,3-diphenylpropan-1-one 

Relevant articles and documents

A rapid, simple route to homochiral α,β-epoxyketones

Substituted E- or Z-acrylylamides derived from a homochiral amine such as (R,R)-2,5-dimethylpyrrolidine or (S,S)-bis(2-phenylethyl)amine are readily epoxidised with complete stereocontrol with t-BuO2Li to give two readily separated, enantiomerically pure diastereomeric epoxides. The easily separated epoxides are efficiently converted into α,β-epoxyketones by the action of organolithiums with 92->99% ee.