246263-95-6

Upstream product

• 38308-93-9 2-tert-butoxycarbonylamino-4-hydroxy-butyric acid benzyl ester 
• 136918-14-4 phthalimide 
• 876617-13-9 L-2-(tert-Butoxycarbonylamino)-4-(benzyloxy)butanoic acid 

Downstream Products

• 246264-02-8 (+/-)-2-(2-phthalimidoethyl)-N-(4-trifluoromethoxybenzensulfonyl)glycine benzyl ester 
• 246264-00-6 (+/-)-N-(4-methoxybenzensulfonyl)-2-(2-phthalimidoethyl)-glycine benzyl ester 
• 246263-99-0 (+/-)-2-(2-Phthalimidoethyl)-N-[4-(pyridin-4-yl)oxybenzensulfonyl]glycine benzyl ester 

Relevant academic research and scientific papers

Synthesis method of 2,4-diaminobutyric acid derivative

The invention belongs to the field of organic chemistry, and particularly relates to a synthesis method of a 2,4-diaminobutyric acid derivative. According to the synthesis method of the 2,4-diaminobutyric acid and the derivative thereof provided by the invention, homoserine is selected as an initial raw material, the amino and carboxyl of the homoserine are protected firstly, a pht group is introduced through a light delay reaction, and then a final product can be obtained through six steps of benzyl ester removal, pht removal and Boc group removal. According to the invention, the synthetic method provided by the invention has relatively high reaction yield and is convenient for separation and purification; the intermediates obtained in the reaction are all protecting group modified aminoacid derivatives and can be directly used as drug intermediates or raw materials for synthesizing other compounds, so that waste is avoided; and the reaction conditions provided by the invention are mild, and later-period amplification production is facilitated.

SULFONAMIDE DERIVATIVES

The object is to provide a compound having matrixmetalloproteinase-13 inhibitory activity and aglycanase inhibitory activity. A compound of the following formula (I) or a pharmacologically acceptable salt, ester or other derivative thereof:{R1: H, NHOH; R2: H, optionally substituted alkyl, cycloalkyl, a group -AR6 [A: an alkylene which may be optionally interrupted by O, -S(O)m- or -N(R9); R6: a group (II), (III), (IV)X: O, S, -N(R10)-, -C(R11)(R12)-; Y: O, CO, -S(O)n-, -N(R10)-, -C(R11)(R12)-; R7, R8: H, alkyl, COOH, optionally subsituted alkyl, etc.; R9, R10, R11,R12: H, alkyl, etc.; m, n: 0 to 2]R3: H, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl; R4: optionally substituted (hetero)arylene; R5: optionally substituted alkyl, optionally substituted (hetero)aryl}.