24629-78-5

Basic information

• Product Name: EXO-(1R)-1,7,7-TRIMETHYLBICYCLO[2.2.1]HEPTAN-2-AMINE HYDROCHLORIDE
• Synonyms: EXO-(1R)-1,7,7-TRIMETHYLBICYCLO[2.2.1]HEPTAN-2-AMINE HYDROCHLORIDE;R(-)-ISOBORNYLAMINE HYDROCHLORIDE;(-)-exo-2-bornanaminehydrochloride;hydrochloride,exo-(-)-2-bornanamin;(1R-exo)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-amine hydrochloride;r-(-)-isobornylamineHCl
• CAS NO: 24629-78-5
• Molecular Formula: C₁₀H₁₉N*ClH
• Molecular Weight: 189.73
• EINECS: 246-373-5
• Mol File: 24629-78-5.mol

Chemical Properties

• Melting Point: ≥300 °C
• Boiling Point: 188.7°C at 760 mmHg
• Flash Point: 48.5°C
• Appearance: /
• Vapor Pressure: 0.591mmHg at 25°C
• BRN: 4196859
• CAS DataBase Reference: EXO-(1R)-1,7,7-TRIMETHYLBICYCLO[2.2.1]HEPTAN-2-AMINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: EXO-(1R)-1,7,7-TRIMETHYLBICYCLO[2.2.1]HEPTAN-2-AMINE HYDROCHLORIDE(24629-78-5)
• EPA Substance Registry System: EXO-(1R)-1,7,7-TRIMETHYLBICYCLO[2.2.1]HEPTAN-2-AMINE HYDROCHLORIDE(24629-78-5)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: ED6183800
• F: 3
• Hazardous Substances Data: 24629-78-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
EXO-(1R)-1,7,7-TRIMETHYLBICYCLO[2.2.1]HEPTAN-2-AMINE HYDROCHLORIDE is used as a pharmaceutical intermediate for the synthesis of various drugs and therapeutic agents. Its chiral nature allows for the development of enantiomerically pure compounds, which can have different biological activities and reduce potential side effects.
Used in Organic Synthesis:
EXO-(1R)-1,7,7-TRIMETHYLBICYCLO[2.2.1]HEPTAN-2-AMINE HYDROCHLORIDE is used as a building block in organic synthesis for the creation of complex organic molecules. Its unique bicyclic amine structure and increased solubility due to the hydrochloride salt form make it a valuable component in the synthesis of various organic compounds.
Used in Research:
EXO-(1R)-1,7,7-TRIMETHYLBICYCLO[2.2.1]HEPTAN-2-AMINE HYDROCHLORIDE is used as a research compound to study its potential biological activity and applications in drug development. Its chiral nature and potential interactions with biological targets make it an interesting subject for research in the fields of medicinal chemistry and pharmacology.

InChI:InChI=1/C10H19N.ClH/c1-9(2)7-4-5-10(9,3)8(11)6-7;/h7-8H,4-6,11H2,1-3H3;1H/t7-,8-,10+;/m1./s1

Upstream product

• 2792-42-9 (R,R)-camphor oxime 
• 464-49-3 (1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one 

Downstream Products

• 128413-94-5 N-(2-Iodo-phenyl)-N'-((1R,2R,4R)-1,7,7-trimethyl-bicyclo[2.2.1]hept-2-yl)-guanidine 
• 1159913-16-2 C₂₂H₃₂ClFN₂ 

Relevant articles and documents

Exploring a pocket for polycycloaliphatic groups in the CXCR3 receptor with the aid of a modular synthetic strategy

A CXCR3 pocket capable of accommodating polycycloaliphatics was explored using a modular synthetic strategy. The systematic studies reveal that the tricyclic 2-adamantane and bicyclic (iso)bornyl group are efficiently recognized by CXCR3.

Synthesis of Optically Active Triazolinediones and Examination of Their Utility for Inducing Asymmetry in Diels-Alder Cycloaddition Reactions

(S)-(-)-α-Methylbenzylamine, dehydroabietylamine, and endo-bornylamine have been transformed into the optically pure triazolinediones via the respective isocyanates and urazoles.Their ability to discriminate between diastereomeric Diels-Alder transition states was determined in the case of two dienes, 2,4-p-menthadiene and α-phellandrene, which were prepared in racemic and optically active forms of known enantiomeric purity.Exhaustive cycloaddition to these dienes gave the needed pairs of adduct D reference points against which those obtained in the asymmetric induction studies could be compared.By this technique, simple plots of D vs. diastereomeric purity served to delineate not only the level of enantioselection but also the absolute configuration of the adducts.Due in part to their exceptionally high reactivity, the triazolinediones are not sufficiently selective to permit high levels of enantioselection.Rather, their usefulness lies in their ability to achieve nondestructive resolution of various nonobivously resolvable compounds.