2465-91-0

Usage

Uses

Used in Pharmaceutical Industry:
Tetra(Cyanoethoxymethyl) Methane is used as a linker for the development of PROTACs, which are a promising class of therapeutics for the targeted degradation of specific proteins. The ability to hydrolyze, reduce, or eject the nitrile groups allows for the fine-tuning of the linker's properties, enhancing the specificity and efficacy of the resulting PROTACs in modulating protein-protein interactions and addressing various disease states.
Used in Chemical Synthesis:
In the field of chemical synthesis, Tetra(Cyanoethoxymethyl) Methane can be employed as a versatile building block for the creation of complex molecules and compounds. The reactivity of the nitrile groups enables a range of chemical reactions, such as hydrolysis, reduction, and cyanide ion ejection, which can be harnessed to synthesize a variety of molecules with diverse applications in different industries.
Used in Research and Development:
Tetra(Cyanoethoxymethyl) Methane serves as a valuable tool in research and development, particularly in the study of protein degradation and the development of novel therapeutic strategies. Its unique properties and reactivity make it an attractive candidate for the design and synthesis of new molecules with potential applications in various fields, including drug discovery, materials science, and biotechnology.

InChI:InChI=1/C17H24N4O4/c18-5-1-9-22-13-17(14-23-10-2-6-19,15-24-11-3-7-20)16-25-12-4-8-21/h1-4,9-16H2

Upstream product

• 115-77-5 Pentaerythritol 
• 107-13-1 acrylonitrile 

Downstream Products

• 35638-19-8 tetrakis(4-carboxy-2-oxabutyl)methane 
• 183370-86-7 tetra(2-pentachloro-phenoxycarbonyl-ethoxymethyl)methane 
• 1049690-42-7 C₄₂H₃₉Cl₁₅N₂O₁₃ 
• 132491-88-4 tetrakis[(carboxyethoxy)methyl]methane tetrachloride 

Relevant academic research and scientific papers

Highly conductive electrolytes derived from nitrile solvents

A series of new low molecular weight nitrile solvents has been designed and synthesized for secondary lithium battery electrolytes. Lithium bis(trifluoromethylsulonyl) imide (LiTFSI) salt concentration and temperature dependent ionic conductivity, electrochemical stability and thermal properties have been studied. The best ionic conductivity, 12.9 × 10-3 S/cm at 25°C, was observed with 1.60M LiTFSI in 2,2-bis(hydroxymethyl)-1,3-propanedi-2-ethylcyano solvent. Both electrolytes and neat solvents displayed freezing point below -80°C.

Synthesis of perfluorinated functionalized, branched ethers

We wish to report synthesis of perfluorinated functionalized, branched ethers from their hydrocarbon analogues by direct fluorination. Yields up to 90%, with high purities, have been obtained at ambient temperature and pressure. This technique will likely develop into a new general method for producing perfluorinated, hyperbranched and dendritic polymers.

Preparation and application of three-branch RGD modified brain glioma targeting lipid material

The invention discloses a three-branch RGD-modified glioma targeting lipid material which is used for targeted delivery of brain glioma treatment drugs. One end of the novel lipid material is connected with cholesterol extending through polyethylene glycol, and the other end of the novel lipid material is connected with RGD peptide with brain glioma targeting function, and the novel lipid material can be used for integrin receptor α which is highly expressed on the surface of brain capillary endothelial cells and brain glioma cells. v β3 The affinity between the brain glioma is achieved through the affinity between the brain glioma, and the effective concentration of the therapeutic drug to the brain tumor is improved. The novel lipid lipid material can be used for liposome. The prepared paclitaxel liposome has obvious brain targeting property and tumor targeting property, and has wide application prospects.

HEPARAN SULFATE GLYCOMIMETIC COMPOUNDS AND THEIR PHARMACEUTICAL AND COSMECEUTICAL USES

The invention relates to dendritic compounds, the use of these compounds as pharmaceuticals, pharmaceutical and cosmeceutical compositions containing the compounds, and methods of treating cancer, inflammation, diabetic nephropathy, neurodegenerative disorders, Niemann-Pick Type C disease, or dermatological conditions.

NUCLEOPHILE-TRIGGERED DEGRADBLE MATERIALS AND METHODS OF MAKING AND USING THE SAME

Disclosed herein are degradable materials comprising the reaction product of an oxanorbomadiene crosslinker or derivative thereof and a multivalent nucleophile-terminated compound, wherein the reaction product is a degradable elastic solid capable of entraining cargo. Also disclosed herein are degradable materials comprising a polymeric and hyperbranched crosslinked material made with oxanorbomadiene linkage that can be activated for cleavage at a predetermined rate by addition of a nucleophile. Also disclosed herein are methods of making and using the same.

Tetrahedral DNA conjugates from pentaerythritol-based polyazides

Branching points in DNA nanostructures are usually 3- or 4-way junctions maintained by Watson-Crick non-covalent interactions. However, covalently bound DNA stars could improve the diversity, strength and integrity of DNA nanoscale constructions. We report here the convenient synthesis of 3- and 4-fold pentaerythritol-based azides and their use for the assembly of branched conjugates containing the same or different oligonucleotides (ODNs) and/or fluorescent dyes by stoichiometry controlled copper (I) catalyzed azide alkyne cycloaddition (CuAAC) functionalization.

Antibodies that inhibit metalloproteins

An antibody is disclosed which comprises an antigen recognition region which comprises six CDR amino acid sequences selected from the group consisting of SEQ ID NOs: 4-15. Uses thereof are also disclosed.

Single-entity heparan sulfate glycomimetic clusters for therapeutic applications

Heparan sulfate (HS) is a highly sulfated glycosaminoglycan with a variety of critical functions in cell signaling and regulation. HS oligosaccharides can mimic or interfere with HS functions in biological systems; however, their exploitation has been hindered by the complexity of their synthesis. Polyvalent displays of small specific HS structures on dendritic cores offer more accessible constructs with potential advantages as therapeutics, but the synthesis of single-entity HS polyvalent compounds has not previously been described. Herein we report the synthesis of a novel targeted library of single-entity glycomimetic clusters capped with varied HS saccharides. They have the ability to mimic longer natural HS saccharides in their inhibition of the Alzheimer's disease (AD) protease BACE-1. We have identified several single-entity HS clusters with IC50 values in the low-nanomolar range. These HS clusters are drug leads for AD and offer a novel framework for the manipulation of heparan sulfate-protein interactions in general.

Multivalent agents containing 1-substituted 2,3,4-trihydroxyphenyl moieties as novel synthetic polyphenols directed against HIV-1

The synthesis and the assessment of the anti-HIV activity of a set of molecules inspired by the multivalent structures of some naturally-occurring polyphenols (tannins) are reported. Different multibranched scaffolds have been derived from pentaerythritol as the central core which distribute spatially synthetic polyphenolic subunits based on 1-substituted 2,3,4-trihydroxyphenyl moieties. A tetrapodal compound (13b) bearing four N-(2,3,4-trihydroxyphenyl) amide groups, exhibits remarkable selective activity against HIV-1 with EC 50 values in the micromolar scale, in the same range as those reported for the most representative anti-HIV tannins. Preliminary SAR studies emphasize the importance of the 1-substituted 2,3,4-trihydroxyphenyl moiety, the presence of an amide as the linker and the multivalent architecture of these molecules, since the anti-HIV activity increases with the number of polyphenolic moieties. The data support the interest in synthetic polyphenols and represent a promising starting point for further design and development of selective HIV-1 inhibitors.

DENDRITIC CORE COMPOUNDS

The invention relates to compounds that are useful for the preparation of dendrimer compounds, the use of these compounds for preparing dendrimers and processes for preparing the compounds.