246511-74-0

Basic information

• Product Name: 3-Hexanone, 2-hydroxy-5-methyl- (9CI)
• Synonyms: 3-Hexanone, 2-hydroxy-5-methyl- (9CI);2-HYDROXY-5-METHYL-3-HEXANONE
• CAS NO: 246511-74-0
• Molecular Formula: C7H14O2
• Molecular Weight: 130.18486
• Product Categories: ACETYLGROUP
• Mol File: 246511-74-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 172.206°C at 760 mmHg
• Flash Point: 63.915°C
• Appearance: /
• Density: 0.933g/cm³
• Vapor Pressure: 0.426mmHg at 25°C
• Refractive Index: 1.429
• CAS DataBase Reference: 3-Hexanone, 2-hydroxy-5-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Hexanone, 2-hydroxy-5-methyl- (9CI)(246511-74-0)
• EPA Substance Registry System: 3-Hexanone, 2-hydroxy-5-methyl- (9CI)(246511-74-0)

Safety Data

• Hazardous Substances Data: 246511-74-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C7H14O2/c1-5(2)4-7(9)6(3)8/h5-6,8H,4H2,1-3H3

Upstream product

• 623-56-3 5-methyl-3-hexanone 
• 623-55-2 (+-)-5-methyl-3-hexanol 
• 72134-96-4 5-methyl-3-trimethylsilyloxy-2-hexene 
• 590-86-3 isovaleraldehyde 
• 13706-86-0 5-methyl-2,3-hexanedione 

Relevant articles and documents

Biosynthesis of Diverse Antimicrobial and Antiproliferative Acyloins in Anaerobic Bacteria

Metabolic profiling and genome mining revealed that anaerobic bacteria have the potential to produce acyloin natural products. In addition to sattazolin A and B, three new sattazolin congeners and a novel acyloin named clostrocyloin were isolated from three strains of Clostridium beijerinckii, a bacterium used for industrial solvent production. Bioactivity profiling showed that the sattazolin derivatives possess antimicrobial activities against mycobacteria and pseudomonads with only low cytotoxicity. Clostrocyloin was found to be mainly active against fungi. The thiamine diphosphate (ThDP)-dependent sattazolin-producing synthase was identified in silico and characterized both in vivo and in in vitro enzyme assays. A related acyloin synthase from the clostrocyloin producer was shown to be responsible for the production of the acyloin core of clostrocyloin. The biotransformation experiments provided first insights into the substrate scope of the clostrocyloin synthase and revealed biosynthetic intermediates.

Synthesis of 2-hydroxy-5-methyl-3-hexanone

2-Hydroxy-5-methyl-3-hexanone, which is a characteristic component of eucalyptus honeys, was synthesised by oxidation of the silyl enol ether of 5-methyl-3-hexanone. 5-Methyl-3-hexanone was prepared by Grignard reaction and oxidation starting from isovaleraldehyde and ethylmagnesium bromide. The desired silyl enol ether was produced with high selectivity by deprotonation of 5-methyl-3-hexanone with NaHMDS in n-hexane followed by reaction with chlorotrimethylsilane and then oxidised by MCPBA to give pure 2-hydroxy-5-methyl-3-hexanone in about 77% yield after purification by flash chromatography. 2-Hydroxy-5-methyl-3-hexanone has a cheese and sour milk odour.