246512-84-5Relevant academic research and scientific papers
Discovery of N-(3-{4-[(3-fluorobenzyl)oxy]phenoxy}propyl)-2-pyridin-4- ylacetamide as a potent and selective reverse NCX inhibitor
Kuramochi, Takahiro,Kakefuda, Akio,Yamada, Hiroyoshi,Ogiyama, Takashi,Taguchi, Taku,Sakamoto, Shuichi
, p. 1043 - 1047 (2005)
In the setting of heart failure and myocardial ischemia-reperfusion, the sodium-calcium exchanger (NCX) can lead to calcium overload, which is responsible for contractile dysfunction and arrhythmia. NCX is an attractive target for treatment in heart failure and myocardial ischemia-reperfusion. We have designed and synthesized a series of benzyloxyphenyl derivatives based on compound 3. These derivatives have been evaluated for their inhibitory activity against both the reverse and forward modes of NCX. We have discovered a novel potent and selective reverse NCX inhibitor (12) with an IC50 value of 0.085 μM against reverse NCX.
