246523-06-8Relevant academic research and scientific papers
Asymmetric synthesis of 3-amino-2-hydroxy-4-phenylbutanoate
Ha, Hyun-Joon,Ahn, Young-Gil,Lee, Gwan Sun
, p. 2327 - 2336 (2007/10/03)
Asymmetric synthesis of 3-amino-2-hydroxy-4-phenylbutanoate, a key component of the natural product bestatin and HIV protease inhibitors of KNI- 272 and R-87366, has been achieved from the stereoselective aldimine coupling reaction between 3-phenyl-2-aminopropanenitrile and (Z)-α-methoxy trimethylsilyl ketene acetal in the presence of Lewis acids.
