246537-04-2Relevant academic research and scientific papers
Design and synthesis of novel pyridazine N-aryl acetamides: In-vitro evaluation of α-glucosidase inhibition, docking, and kinetic studies
Faramarzi, Mohammad Ali,Firoozpour, Loghman,Foroumadi, Alireza,Moghimi, Setareh,Mojtabavi, Somayeh,Sadat Ebrahimi, Seyed Esmaeil,Safari, Fatemeh,Salarinejad, Somayeh,Toolabi, Mahsa
, (2020/07/21)
We herein applied the four step-synthetic route to prepare the pyridazine core attached to the various N-aryl acetamides. By this approach, a new series of pyridazine-based compounds were synthesized, characterized and evaluated for their activities against α-glucosidase enzyme. In-vitro α-glucosidase assay established that twelve compounds are more potent than acarbose. Compound 7a inhibited α-glucosidase with the IC50 value of 70.1 μM. The most potent compounds showed no cytotoxicity against HDF cell line. Molecular docking and kinetic studies were performed to determine the modes of interaction and inhibition, respectively.
Synthesis of novel thieno[2,3-c]pyridazines and related heterocycles
Radwan, Shaban M.,Bakhite, Etify A.
, p. 1117 - 1128 (2007/10/03)
The reaction of ethyl 2,3-dihydro-5,6-diphenyl-3-thioxopyridazine-4-carboxylate with ω-bromoacetophenones, chloro-N-arylacetamides, chloroacetonitrile, ethyl chloroacetate, or chloroacetone furnished the corresponding 4,5-diphenyl-3-hydroxy thieno [2,3-c]pyridazines. 2-Cyano-, 2-ethoxycabonyl-, and 2-acetyl-4,5-diphenyl-3-hydroxythieno[2,3-c]pyridazines were employed as precursors in the synthesis of some novel furo [2′,3′:4,5]thieno[2,3-c]pyridazines, pyrano-[2′,3′:4,5]thieno[2,3-c]pyridazines, and thieno[2,3-c]pyridazines. The antibacterial and antifungal activities of some of the compounds are reported.
