24654-86-2Relevant academic research and scientific papers
A simple and effective synthesis of activated vinylphosphonates from 3-methoxy-2-diethoxyphosphorylacrylate
Janecki, Tomasz,Albrecht, Anna,Koszuk, Jacek F.,Modranka, Jakub,S?owak, Dominika
experimental part, p. 2274 - 2276 (2010/05/18)
A facile, efficient and general one-step procedure for the synthesis of 3-substituted 2-diethoxyphosphorylacrylates from 3-methoxy-2-diethoxyphosphorylacrylate 1b and nitrogen, carbon and phosphorus nucleophiles is presented. Reaction of 1b with 3,5-dimethoxyphenol in the presence of trifluoromethanesulfonic acid yields 3-diethoxyphosphoryl-5,7-dimethoxychromen-2-one.
DIALKYL FORMYL-1 METHYLPHOSPHONATES α-FONCTIONNELS-II. PREPARATION PAR VOIE THERMIQUE ET TRANSFORMATION EN HETEROCYCLES α-PHOSPHONIQUES
Aboujaoude, Elie Elia,Collignon, Noel,Savignac, Philippe
, p. 427 - 434 (2007/10/02)
The thermal condensation of functional phosphonates bearing strongly withdrawing groups (RO)2P(O)CH2Z 1 with dimethylformamide dimethyl acetal gives corresponding β-functional, β-phosphonic enamines (RO)2P(O)C(Z)=CHNMe2 2.Acid or basic hydrolysis of the enamines frequently gives the free aldehyde (RO)2P(O)CH(Z)-CHO 3.We show that the enamines can be used with success for the synthesis of heterocycles like, pyrazoles 4, pyrimidines 5, benzodiazepine 6 or indole 7, all of them substituted with a phosphonate group.
