246545-73-3Relevant academic research and scientific papers
2-triazenopyrroles: Synthesis and biological activity
Diana, Patrizia,Barraja, Paola,Lauria, Antonino,Almerico, Anna Maria,Cirrincione, Girolamo,Loi, Anna Giulia,Musiu, Chiara,Pani, Alessandra,La Colla, Paolo,Marongiu, Maria Elena
, p. 353 - 360 (1999)
2-Triazenopyrroles were synthesized by coupling the corresponding 2- diazopyrroles with secondary amines and tested for antiproliferative, antifungal, antiviral and antibacterial activities. Derivative 9m was the most cytotoxic, showing, against leukaemia, lymphoma and carcinoma cell lines, IC50 3.9-21 μM and inhibited Cox-B2 and VSV with EC50 10 μM. Derivative 9j, instead, was active against C. albicans with a selectivity index higher than that of miconazole.
Pyrrolo[2,1-d][1,2,3,5]tetrazines, a new class of azolotetrazines related to the antitumor drug temozolomide
Diana, Patrizia,Barraja, Paola,Lauria, Antonino,Almerico, Anna Maria,Dattolo, Gactano,Cirrincione, Girolamo
, p. 2082 - 2086 (2007/10/03)
A series of derivatives of the new ring system pyrrolo[2,1- d][1,2,3,5]tetrazine, potential antineoplastic agents, were obtained in good yield from the reaction of 2-diazopyrroles with isocyanates at room temperature and in the dark. Atomic charges at C-4
