24680-04-4

Upstream product

• 4743-17-3 5-Chloroisatoic anhydride 
• 106-47-8 4-chloro-aniline 
• 188604-94-6 5-chloro-N-(4-chlorophenyl)-2-nitrobenzamide 
• 41994-44-9 5-chloro-2-nitrobenzoyl chloride 
• 2516-95-2 5-chloro-2-nitrobenzoic acid 

Downstream Products

• 123333-40-4 N-(2-amino-5-chloro-benzyl)-4-chloro-aniline 
• 229339-69-9 N-(4-chlorophenyl)-2-[((3-chloro-6-methylbenzo[b]thien-2-yl)carbonyl)amino]-5-chlorobenzamide 
• 229343-18-4 C₁₉H₁₃Cl₃N₂O₂S 
• 229342-64-7 3-chloro-N-(4-chloro-2-{[(4-chlorophenyl)amino]carbonyl}phenyl)-4-(chloromethyl)-2-thiophenecarboxamide 
• 229342-75-0 3-chloro-N-(4-chloro-2-{[(4-chlorophenyl)amino]carbonyl}phenyl)-4,5-bis(chloromethyl)-2-thiophenecarboxamide 
• 229339-70-2 N-(4-chlorophenyl)-2-[((3-methylbenzo[b]thien-2-yl)carbonyl)amino]-5-chlorobenzamide 
• 1217358-68-3 C₂₁H₁₃Cl₂N₃O₂ 

Relevant academic research and scientific papers

Substituted thiophene-anthranilamides as potent inhibitors of human factor Xa

A series of thiophene-containing non-amidine factor Xa inhibitors is described. Simple methyl-substituted thiophene analogs were relatively weak inhibitors. However, introduction of hydrophilic substituents at C-4 or C-5 of the thiophene afforded inhibito

Structure-activity relationships of substituted benzothiophene-anthranilamide factor Xa inhibitors

Compound 1 was identified by high throughput screening as a novel, potent, non-amidine factor Xa inhibitor with good selectivity against thrombin and trypsin. A series of modifications of the three aromatic groups of 1 was investigated. Substitution of chlorine or bromine for fluorine on the aniline ring led to the discovery of subnanomolar factor Xa inhibitors. Positions on the anthranilic acid ring that can accommodate further substitution were also identified.