246848-28-2

Upstream product

• 81779-73-9 chloroxoacetic acid (4-nitrophenyl)methyl ester 
• 246848-27-1 Carbonic acid isobutyl ester (R)-2-oxo-3-[(2R,3S)-4-oxo-3-((R)-1-triethylsilanyloxy-ethyl)-azetidin-2-yl]-butyl ester 
• 246848-26-0 Carbonic acid (R)-3-[(2R,3S)-3-((R)-1-hydroxy-ethyl)-4-oxo-azetidin-2-yl]-2-oxo-butyl ester isobutyl ester 
• 543-27-1 isobutyl chloroformate 
• 246848-24-8 3-oxobutyl isobutyl carbonate 
• 994-30-9 triethylsilyl chloride 

Downstream Products

• 246848-23-7 [4S-[4α,5β,6β(S*)]]-4-methyl-3-[[[(2-methylpropoxy)carbonyl]oxy]methyl]-7-oxo-6-[1-[(triethylsilyl)oxy]ethyl]-1-azabicyclo[3.2.0]hepten-2-ene-2-carboxylic acid (4-nitrophenyl)methyl ester 

Relevant academic research and scientific papers

Efficient and practical synthesis of a potent anti-MRSA β- methylcarbapenem containing a releasable side chain

We describe a convergent synthesis of the MRSA β-methyl carbapenem 1, wherein the molecule is assembled from the naphthosultam side chain 2 and the allylic carbonate of the β-Me carbapenem piece 6. The β-Me stereochemistry of 6 is set up in a novel titani