246868-49-5Relevant academic research and scientific papers
Substituted tricyclics
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, (2008/06/13)
A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA2mediated release of fatty acids for treatment of conditions such as septic shock.
Substituted tricyclics useful in sPLA2 induced diseases
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, (2008/06/13)
A class of novel tricyclics is diclosed of the formula (I) : is phenyl or pyridyl wherein the nitrogen is at the 5-, 6-, 7- or 8-position; one of B or D is nitrogen and the other is carbon; is cyclohexenyl, phenyl, pyridyl, wherein the nitrogen is at the 1 -, 2-, or 3position, or a 6-membered hetero-cyclic ring having one heteroatom selected from the group consisting of sulfur or oxygen at the 1-, 2- or 3-position, and nitrogen at the 1 -, 2-, 3- or 4-position; is a double or single bond; together with the use of such compounds for inhibiting SPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
