2469-18-3Relevant academic research and scientific papers
Silver-Catalyzed Radical Transformation of Aliphatic Carboxylic Acids to Oxime Ethers
Zhu, Yuchao,Wen, Xiaojin,Song, Song,Jiao, Ning
, p. 6465 - 6472 (2016/10/14)
Oximes and oxime ethers are privileged building blocks and can be conveniently converted to ketones, amines, hydroxylamines, and nitriles. We describe the catalytic decarboxylation of aliphatic carboxylic acids to oxime ethers. With AgNO3 as the catalyst, valuable oxime ethers bearing various substituents could be easily obtained. The broad substrate scope, easy accessibility of aliphatic carboxylic acids, and mild reaction conditions make this strategy immediately applicable to the synthesis, late-stage functionalization, and modification of biologically active compounds. Experimental studies show the reaction undergoes a radical process.
