247017-85-2

Basic information

• Product Name: 3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid chloromethyl ester
• Synonyms: 3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid chloromethyl ester
• CAS NO: 247017-85-2
• Molecular Weight: 588.06
• Mol File: 247017-85-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid chloromethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid chloromethyl ester(247017-85-2)
• EPA Substance Registry System: 3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid chloromethyl ester(247017-85-2)

Safety Data

• Hazardous Substances Data: 247017-85-2(Hazardous Substances Data)

Upstream product

• 22128-62-7 carbonochloridic acid, chloromethyl ester 
• 158991-23-2 PD 154075 

Downstream Products

• 247017-86-3 3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid iodomethyl ester 
• 247017-87-4 3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid bis-benzyloxy-phosphoryloxymethyl ester 
• 247017-91-0 3-[(R)-2-(Benzofuran-2-ylmethoxycarbonylamino)-2-((S)-1-phenyl-ethylcarbamoyl)-propyl]-indole-1-carboxylic acid 4-(bis-benzyloxy-phosphoryloxymethyl)-benzoyloxymethyl ester 

Relevant articles and documents

Phosphate prodrugs of PD154075

In the preparation of phosphate prodrugs of PD154075, several strategies of linking a phosphate group to the indole moiety were studied. A novel linker, p-hydroxymethylbenzoyloxymethoxycarbonyl, was discovered to provide the phosphate prodrug of PD154075 (compound 9) with significantly increased aqueous solubility, sufficient stability in aqueous solution and good bio-reconversion in vivo. (C) 2000 Elsevier Science Ltd. All rights reserved.