247025-10-1

Basic information

• Product Name: 3-Azido-3-deoxy-4-hydroxy-methyl-1,2-O-isopropylidene-α-D-ribofuranose
• Synonyms: 3-Azido-3-deoxy-4-hydroxy-methyl-1,2-O-isopropylidene-α-D-ribofuranose;3-Azido-3-deoxy-4-C-(hydroxyMethyl)-1,2-O-(1-Methylethylidene)-α-D-erythro-pentofuranose
• CAS NO: 247025-10-1
• Molecular Formula: C₉H₁₅N₃O₅
• Molecular Weight: 245.2325
• Product Categories: 13C & 2H Sugars;Carbohydrates & Derivatives
• Mol File: 247025-10-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 110-112°C
• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: DMF, DMSO, Ethanol, Methanol
• CAS DataBase Reference: 3-Azido-3-deoxy-4-hydroxy-methyl-1,2-O-isopropylidene-α-D-ribofuranose(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Azido-3-deoxy-4-hydroxy-methyl-1,2-O-isopropylidene-α-D-ribofuranose(247025-10-1)
• EPA Substance Registry System: 3-Azido-3-deoxy-4-hydroxy-methyl-1,2-O-isopropylidene-α-D-ribofuranose(247025-10-1)

Safety Data

• Hazardous Substances Data: 247025-10-1(Hazardous Substances Data)

Usage

Chemical Properties

White to Off-White Solid

Upstream product

• 153915-02-7 C₂₄H₂₃F₃O₁₀S 
• 153914-97-7 5-O-benzoyl-4-benzoyloxymethyl-1,2-O-isopropylidene-α-D-xylofuranose 
• 230631-15-9 5-O-Benzoyl-4-C-benzoyloxymethyl-3-O-benzyl-1,2-O-isopropylidene-β-L-threo-pentofuranose 
• 72261-44-0 1,2-O-isopropylidene-3-O-benzyl-4-C-(hydroxymethyl)-β-L-threo-pento-1,4-furanose 
• 23558-05-6 3-O-benzyl-1,2-O-isopropylidene-1,5-D-xylo-dialdofuranose 
• 908142-25-6 1-2 O-isopropylidene 3-O-benzyl α(D)gluco-pentoaldofuranose 
• 591727-19-4 1-2,5-6 di-O-isopropylidene 3-O-benzyl α(D)gluco-pentoaldofuranose 
• 350255-13-9 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose 
• 153914-98-8 3-Azido-5-O-benzoyl-4-C-benzoyloxymethyl-3-deoxy-1,2-O-isopropylidene-α-D-ribofuranose 

Downstream Products

• 247025-16-7 3'-azido-5'-O-tert-butyldiphenylsilyl-3'-deoxy-2'-O,4'-C-methylene-5-methyluridine 
• 345235-45-2 Acetic acid (3R,4S,5R)-4-azido-5-[(6-benzoylamino-purin-9-yl)-methoxy-methyl]-3-trimethylsilanyloxy-tetrahydro-furan-3-ylmethyl ester 
• 551934-09-9 3-azido-5-O-acetyl-3-deoxy-4-C-(p-toluenesulfonyloxymethyl)-1,2-O-isopropylidene-α-D-erythro-ribofuranose 
• 247025-11-2 3'-azido-5'-O-tert-butyldiphenylsilyl-3'-deoxy-4'-hydroxymethyl-1',2'-O-isopropylidene-α-D-ribofuranose 

Relevant articles and documents

MODIFIED NUCLEOSIDE PHOSPHORAMIDITES

The present disclosure relates to compounds and compositions containing 5'-phosphoramidite nucleoside monomers of formulae (I) and (II), and methods of making and use, wherein the substituents are as defined in the appended claims.

NOVEL BICYCLONUCLEOSIDE ANALOGUES

This invention provides novel bicyclonucleoside analogues which exhibit anti-AIDS activity and intermediates to produce oligonucleotide analogues which have anti-sense or anti-gene activity as well as in vivo stability. The present invention is compounds

Synthesis of a conformationally locked AZT analogue, 3'-azido-3'-deoxy- 2'-O,4'-C-methylene-5-methyluridine

A bicyclic 3'-azido-3'-deoxythymidine (AZT) analogue with a locked N- conformation, 3'-azido-3'-deoxy-2'-O,4'-C-methylene-5-methyluridine (1a), and its 3'-amino derivative, 3'-amino-3'-deoxy-2'-O,4'-C-methylene-5- methyluridine (1b), were successfully synthesized from D-glucose. The conformation of 1a was also discussed by means of 1H NMR measurements and a molecular modeling (PM3) study.