247043-57-8Relevant articles and documents
Inhibitory effects of N-(acryloyl)benzamide derivatives on tyrosinase and melanogenesis
Lee, Sanggwon,Ullah, Sultan,Park, Chaeun,Won Lee, Hee,Kang, Dongwan,Yang, Jungho,Akter,Park,Chun, Pusoon,Moon, Hyung Ryong
, p. 3929 - 3937 (2019)
Targeting of tyrosinase has proven to be the best means of identifying safe, efficacious, and potent tyrosinase inhibitors for whitening skin. We designed and synthesized ten NAB (N-(acryloyl)benzamide) derivatives (1a–1j) using the Horner-Wadsworth-Emmon
Catalytic Asymmetric Total Syntheses of Quinine and Quinidine
Raheem, Izzat T.,Goodman, Steven N.,Jacobsen, Eric N.
, p. 706 - 707 (2007/10/03)
The catalytic, asymmetric syntheses of quinine and quinidine were achieved in 16 steps. The recently developed salen(Al)-catalyzed enantioselective Michael addition of methyl cyanoacetate served to set the crucial C4 stereocenter in 92% ee, and a late-stage asymmetric dihydroxylation was used to differentiate the common intermediate and access the two desired diastereomeric products with high selectivity. Copyright
A Practical Synthesis of α,β-Unsaturated Imides, Useful Substrates for Asymmetric Conjugate Addition Reactions
Goodman, Steven N.,Jacobsen, Eric N.
, p. 953 - 956 (2007/10/03)
We report an improved synthesis of α,β-unsaturated imides, a class of compounds that has been identified as broadly useful in (salen)aluminum-catalyzed asymmetric conjugate addition reactions. An efficient, scaleable procedure for the synthesis of phospho