247045-10-9Relevant academic research and scientific papers
Synthesis and spectroscopic evaluation of two novel glycosylated zinc(II)-phthalocyanines
B?chle, Felix,Hanack, Michael,Ziegler, Thomas
, p. 18367 - 18386 (2015)
In continuation of our work on glycoconjugated phthalocyanines, two new water soluble, non-ionic zinc(II) phthalocyanines have been prepared and fully characterized by means of 1H-NMR, 13C-NMR, MALDI-TOF, ESI-TOF, UV-Vis spectroscopy, emission spectroscopy and fluorescence lifetime measurements. The carbohydrate-containing phthalonitrile precursors were synthesized through a copper-catalyzed azide-alkyne cycloaddition (CuAAC). The 2-methoxyethoxymethyl protecting group (MEM) was used to protect the carbohydrate moieties. It resisted the harsh basic cyclotetramerization conditions and could be easily cleaved under mild acidic conditions. The glycoconjugated zinc(II) phthalocyanines described here have molar extinction coefficents smax > 105 M1 cm1 and absorption maxima λ > 680 nm, which make them attractive photosensitizers for photo-dynamic therapy.
