247074-07-3

Upstream product

• 69395-15-9 2-(2-chloro-4-nitro-phenyl)-ethanol 
• 1026652-81-2 2-chloro-1-(2-methoxymethoxy-ethyl)-4-nitro-benzene 
• 247074-05-1 3-chloro-4-[2-(methoxymethoxy)ethyl]aniline 

Downstream Products

• 247073-85-4 2-(3-Chloro-4-{2-[(1S,2R)-2-hydroxy-2-(4-hydroxy-phenyl)-1-methyl-ethylamino]-ethyl}-phenylamino)-2-methyl-propionic acid ethyl ester 

Relevant academic research and scientific papers

2-methylpropionic acid derivatives and pharmaceutical compositions comprising the same

The present invention provides novel 2-methylpropionic acid derivatives represented by the general formula: (wherein R1 represents a hydroxy group, a lower alkoxy group or an aralkyl group; R2 represents a hydroxy group, a lower alkyl group or a halogen atom; A represents an oxygen atom or an imino group; the carbon atom marked with (R) represents a carbon atom in R configuration; and the carbon atom marked with (S) represents a carbon atom in S configuration) and pharmaceutically acceptable salts thereof, which have excellent β3-adrenoceptor stimulating effects and are useful as agents for the prevention or treatment of obesity, hyperglycemia, the diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression, or the diseases caused by biliary calculi or hypermotility of biliary tract.

Discovery of novel N-phenylglycine derivatives as potent and selective β3-adrenoceptor agonists for the treatment of frequent urination and urinary incontinence

With a novel assay using isolated ferret detrusor to estimate β3-adrenoceptor agonistic activity, we found that a series of glycine derivatives of ritodrine, a β2-adrenoceptor agonist, are potent β3-adrenoceptor agonists,