247077-89-0Relevant articles and documents
A synthetic heparan sulfate pentasaccharide, exclusively containing L-iduronic acid, displays higher affinity for FGF-2 than its D-glucuronic acid-containing isomers
Kovensky, Jose,Duchaussoy, Philippe,Bono, Francoise,Salmivirta, Markku,Sizun, Philippe,Herbert, Jean-Marc,Petitou, Maurice,Sinay, Pierre
, p. 1567 - 1580 (2007/10/03)
It has been suggested that the FGF-2 binding site on heparan sulfate chains is a trisulfated pentasaccharide containing three hexuronic acid units. The configuration at C-5 of two of them being undetermined, we have synthesized the four possible pentasaccharides, and have evaluated their FGF-2 binding affinity through in vitro biological assays. The pentasaccharide containing L-iduronic acid as the sole hexuronic acid showed higher affinity for FGF-2 than the other pentasaccharides, where one hexuronic acid unit at least is D-glucuronic acid. Copyright (C) 1999.