247083-15-4

Upstream product

• 110-85-0 piperazine 
• 247083-09-6 6-bromo-1-trityl-1H-benzo[d]imidazole 
• 4887-88-1 5-bromo-1H-benzo[d]imidazole 
• 4887-88-1 6-bromo-1H-benzo[d]imidazole 
• 76-83-5 trityl chloride 

Downstream Products

• 247083-17-6 2-[4-[4-(1-tritylbenzimidazol-6-yl)piperazin-1-yl]butyl]-1,3-dioxoperhydropyrrolo[1,2-c]imidazole 

Relevant academic research and scientific papers

Pd(0) amination of benzimidazoles as an efficient method towards new (benzimidazolyl)piperazines with high affinity for the 5-HT(1A) receptor

New (benzimidazolyl)amines have been synthesized from 4- and 6- bromobenzimidazole derivatives via palladium-mediated amination reactions. Among them, (benzimidazol-4(7)-yl)piperazine derivatives have been shown to be a new family of high affinity 5-HT(1A) receptor ligands. (C) 2000 Elsevier Science Ltd.

Synthesis of new (benzimidazolyl)piperazines with affinity for the 5- HT(1A) receptor via Pd(0) amination of bromobenzimidazoles

The synthesis of a new family of (benzimidazolyl)piperazines has been developed through Pd(0) mediated amination of 4- and 6-bromobenzimidazole derivatives. Preliminary studies showed that some of these compounds are potent 5-HT(1A) receptor ligands.