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247090-55-7

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247090-55-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 247090-55-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,4,7,0,9 and 0 respectively; the second part has 2 digits, 5 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 247090-55:
(8*2)+(7*4)+(6*7)+(5*0)+(4*9)+(3*0)+(2*5)+(1*5)=137
137 % 10 = 7
So 247090-55-7 is a valid CAS Registry Number.

247090-55-7Downstream Products

247090-55-7Relevant articles and documents

Arylisothiocyanato selective androgen receptor modulators (SARMs) for prostate cancer

Hwang, Dong Jin,Yang, Jun,Xu, Huiping,Rakov, Igor M.,Mohler, Michael L.,Dalton, James T.,Miller, Duane D.

, p. 6525 - 6538 (2007/10/03)

A new series of androgen receptor targeted agents (ARTA) was prepared and tested in androgen-dependent and -independent prostate cancer cell lines. These agents were bicalutamide analogs with isothiocyanato substituted B-rings. Also, the linker sulfone of R-bicalutamide was maintained or replaced with several alternative linkages including ether, amine, N-methylamine, thioether, and methylene (in this case the product was a racemic mixture) functional groups at the X-position. To expand the structure-activity relationship (SAR) of these arylisothiocyanato AR ligands, B-ring halogenated arylisothiocyanato ligands were also prepared and tested. The arylisothiocyanato AR ligands showed strong binding affinities to AR ranging from 0.6 to 54 nM. Among them, thioether and ether linkages demonstrated high binding affinities (0.6 and 4.6 nM, respectively) and selective cell growth inhibition (approximately 3- to 6-fold) for LNCaP, an androgen-dependent prostate cancer cell line, when compared to the androgen independent prostate cell lines (DU145, PC-3, and PPC-1) and a bladder cell line (TSU-Pr1). However, the ligands were inactive (IC50>100 mM) in a normal monkey kidney cell line (CV-1) that was used as the control for non-specific toxicity.

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