247102-02-9

Upstream product

• 24242-19-1 5-aminonicotinic acid 
• 532-55-8 Benzoyl isothiocyanate 

Downstream Products

• 1541197-03-8 (S)-3-(3,5-di-tert-butylphenyl)-3-(2-(5-guanidinonicotinamido)acetamido)propanoic acid 
• 1541198-94-0 (S)-ethyl 3-(3,5-di-tert-butylphenyl)-3-(2-(5-guanidinonicotinamido)acetamido)propanoate 
• 1541196-98-8 (3S)-3-(3-bromo-5-(tert-butyl)phenyl)-3-(2-(5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)nicotinamido)acetamido)propanoic acid 
• 1541198-88-2 (3S)-ethyl 3-(3-bromo-5-(tert-butyl)phenyl)-3-(2-(5-((5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino)nicotinamido)acetamido)propanoate 
• 1541196-92-2 (S)-3-(3-bromo-5-(tert-butyl)phenyl)-3-(2-(5-guanidinonicotinamido)acetamido)propanoic acid 
• 1541198-85-9 (S)-ethyl 3-(3-bromo-5-(tert-butyl)phenyl)-3-(2-(5-guanidinonicotinamido)acetamido)propanoate 
• 247099-90-7 (3R)-3-(3-bromo-5-chloro-2-hydroxyphenyl)-3-{[N-({5-[(5-hydroxy-1,4,5,6-tetrahydropyrimidin-2-yl)amino]pyridin-3-yl}carbonyl)glycyl]amino}-propanoic acid 
• 727417-38-1 C₂₁H₂₂BrClN₆O₆C₂H₄ 
• 726190-88-1 C₂₁H₂₁N₆O₅FCl₂C₂H₄ 

Relevant academic research and scientific papers

META-AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS PAN INTEGRIN ANTAGONISTS

The present disclosure provides pharmaceutical agents of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods of using the pharmaceutical agents for the treatment of a variety of diseases and disorders are also provided.

BETA AMINO ACID DERIVATIVES AS INTEGRIN ANTAGONISTS

Disclosed herein are novel pharmaceutical agents which are useful as integrin receptor antagonists that mediate the pathologic processes of angiogenesis and fibrosis and as such are useful in pharmaceutical compositions and in methods for treating conditions mediated by these integrins by inhibiting or antagonizing these integrins. The novel pharmaceutical agents include those of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such pharmaceutical agents. Methods and intermediates useful for making the pharmaceutical agents and methods of using the pharmaceutical agents are also provided.

R-Isomers of Arg-Gly-Asp (RGD) mimics as potent αvβ3 inhibitors

The integrin αvβ3, vitronectin receptor, is expressed in a number of cell types and has been shown to mediate adhesion of osteoclasts to bone matrix, vascular smooth muscle cell migration, and angiogenesis. We recently disclosed the

THE R-ISOMER OF BETA AMINO ACID COMPOUNDS AS INTEGRIN RECEPTOR ANTAGONISTS DERIVATIVES

The present invention relates to a class of compounds represented by the Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula (I), and methods of selectively inhibiting or antagonizing the αVβ3 and/or the αV β5 integrin without significantly inhibiting the αV β6 integrin