247157-95-5

Upstream product

• 247157-96-6 1-methyl-4-[2-(2-nitrovinyl)phenyl]piperazine 

Downstream Products

• 886593-12-0 1-(2,2-dimethoxyethyl)-3-{2-[2-(4-methylpiperazin-1-yl)phenyl]ethyl}-urea 
• 886593-47-1 5-bromo-2-(3-{2-[2-(4-methyl-piperazin-1-yl)-phenyl]-ethyl}-ureido)-benzoic acid methyl ester 
• 886593-51-7 5-bromo-2-(2-[2-(4-methyl-piperazin-1-yl)-phenyl]-ethyl)-isoindole-1,3-dione 
• 886592-55-8 4-tert-butyl-N-{2-[2-(4-methylpiperazin-1-yl)phenyl]-ethyl}-phthalamic acid 
• 886592-56-9 5-tert-butyl-N-{2-[2-(4-methylpiperazin-1-yl)phenyl]-ethyl}-phthalamic acid 
• 886593-50-6 4-bromo-2-methylamino-N-{2-[2-(4-methylpiperazin-1-yl)-phenyl]ethyl}-benzamide 
• 886592-93-4 4-bromo-2-(2-{2-[2-(4-methylpiperazin-1-yl)-phenyl]ethylamino}-ethyl)benzonitrile 
• 886592-68-3 4-{2-[2-(4-methyl-piperazin-1-yl)-phenyl]-ethylcarbamoyl}-biphenyl-3-carboxylic acid ethyl ester 
• 886592-69-4 3-{2-[2-(4-methyl-piperazin-1-yl)-phenyl]-ethylcarbamoyl}-biphenyl-4-carboxylic acid ethyl ester 
• 886593-42-6 N-{2-[2-(4-methylpiperazin-1-yl)phenyl]ethyl}(2-nitrophenyl)amine 

Relevant academic research and scientific papers

PIPERAZINYLPHENALKYL LACTAM/AMINE LIGANDS FOR THE 5HT1B RECEPTOR

The present invention relates to novel derivatives, that are compounds of Formula (I), wherein R1, R2, R3, R14, X, Y, n and m are defined herein, their pharmaceutically acceptable salts, pharmaceutical compositions and methods using said compounds in treating or preventing depression, anxiety, obsessive compulsive disorder (OCD) and other disorders for which selective antagonists, inverse agonists and partial agonists of serotonin 1 (5-HT1) receptors, specifically, antagonists of 5-HT1B are useful.

N-acyl and N-aroyl aralkyl amides as serotonergic agents

A compound of the formula wherein m, R1, R2, R3, R4, R5and X are as defined above, useful in treating or preventing migraine, depression and other disorders for which a 5-HT1agonist or anta