247174-87-4Relevant academic research and scientific papers
Synthesis and antiproliferative activity of novel 3-(indazol-3-yl)- quinazolin-4(3H)-one and 3-(indazol-3-yl)-benzotriazin-4(3H)-one derivatives
Raffa, Demetrio,Daidone, Giuseppe,Maggio, Benedetta,Schillaci, Domenico,Plescia, Fabiana
, p. 317 - 320 (2007/10/03)
Several new 3-(indazol-3-yl)-quinazolin-4(3H)-one and 3-(indazol-3-yl)- benzotriazin-4(3H)-one derivatives 5 and 6 were synthesized and tested for their in vitro antiproliferative activity against Raji, K562, and K562-R cell lines. The pharmacological screening showed that some 2, 6, or 7-substituted quinazolinones 5 posses a significant antiproliferative activity, with a percentage growth inhibition ranging from 44.8% to 100% at 50 μM, which was higher than that showed by the unsubstituted derivative 5a previously synthesized. For the most active compounds 5d, 5f, and 5g the IC50 were recorded.
