247186-16-9

Upstream product

• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 247186-15-8 (tert-butoxycarbonyl)-L-phenylalanine-hexahydropyridazine-3S-carboxylic acid methyl ester 
• 222556-21-0 (S)-tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-methyl ester 
• 138323-07-6 methyl (S)-hexahydropyridazine-3-carboxylate 
• 13734-41-3 t-Boc-L-valine 

Downstream Products

• 519002-51-8 (E)-(2R,3S,4S)-3-tert-butyldimethylsilyloxy-2,4-dimethyl-oct-en-1-oyl-L-valine-L-phenylalanine-hexahydropyridazine-3S-carboxylic acid hex-5-enyl ester 
• 519002-55-2 (E)-(2R,3R,4S)-3-tert-butyldimethylsilyloxy-2,4-dimethyl-oct-6-en-1-oyl-L-valine-L-phenylalanine-hexahydropyridazine-3S-carboxylic acid hex-5-enyl ester 
• 519002-59-6 (E)-(2R,3R,4S)-3-tert-butyldimethylsilyloxy-2,4-dimethyl-oct-6-en-1-oyl-L-valine-L-phenylalanine-hexahydropyridazine-3S-carboxylic acid hexa-3,5-dienyl ester 

Relevant academic research and scientific papers

Macrolide analogues of the novel immunosuppressant sanglifehrin: New application of the ring-closing metathesis reaction

Macrocycles containing a conjugated 1,3-diene moiety have been synthesized for the first time in good yields by the ring-closing metathesis reaction [Eq. (1)]. The new compounds represent cyclophilin-binding, simplified analogues of the macrocyclic core of sanglifehrin A, an immunosuppressant which binds with high affinity to cyclophilin.