247188-47-2Relevant academic research and scientific papers
Cytokine production inhibitors
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, (2008/06/13)
A compound selected from the group consisting of a 5,6-dihydro-α-pyrone of formula (I): wherein bond a is oriented eitheror; X is O or NH; R1is selected from the group consisting of: a group R3(O)C— wherein R3is selected from the group consisting of: (i) a group of formula R4—CH═CH— wherein R4is C1-C20alkyl, C2-C20alkenyl, an aryl group, or a 5- or 6-membered unsaturated heterocyclic ring containing one or two O, N or S atoms, (ii) C2-C20alkyl; and (iii) an aryl group or a substituent which is a fused ring system of formula (1) or (2): ?wherein each of R′ and R″, which are the same or different and may occupy any position on ring a or ring b of said fused ring system, is H or C1-C6alkyl; a group ArCH2— wherein Ar is an aryl group; and a group R5O—CH2— wherein R5is C1-C6alkyl optionally interrupted by one or two O atoms; and R2is CH3or, when R1is a group of formula (A) as defined below, R2is R6OOC— or R6NOC— wherein R6is C1-C6alkyl; and the pharmaceutically and veterinarily acceptable salts and esters thereof; with the exception of compounds wherein bond a is oriented, X is O and R1is a group of formula (A): ?wherein R11and R21are H when R2in formula (I) is CO2H or CH3, or one of R11and R21is H and the other is OH when R2in formula (I) is CO2H.
