247193-45-9Relevant academic research and scientific papers
Synthesis and in vitro evaluation of novel 2,6,9-trisubstituted purines acting as cyclin-dependent kinase inhibitors
Legraverend, Michel,Ludwig, Odile,Bisagni, Emile,Leclerc, Sophie,Meijer, Laurent,Giocanti, Nicole,Sadri, Ramin,Favaudon, Vincent
, p. 1281 - 1293 (1999)
Novel C-2, C-6, N-9 trisubstituted purines derived from the olomoucine/roscovitine lead structure were synthesized and evaluated for their ability to inhibit starfish oocyte CDK1/cyclin B, neuronal CDK5/p35 and erk1 kinases in purified extracts. Structure
