2472-16-4Relevant articles and documents
CARBAPENEM DERIVATIVES CONTAINING A BICYCLIC KETONE SUBSTITUENT AND THEIR USE AS ANTI-INFECTIVES
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, (2008/06/13)
The present invention relates to carbapenems and provides a compound of the formula (I) wherein R1 is hydroxymethyl, 1-hydroxyethyl or 1-fluoroethyl; R2 is hydrogen or C1-4alkyl; X1 is oxygen or sulphur; and A is of the formula which is optionally substituted on either ring and wherein B is of the formula -CH2-C(=0)-(CH2)n-, -C(=0)-(CH2)n1-, -C(=0)-CH=CH-X2-, -C(=O)CH2CH2X2_(CH2)nC(=O)NH- or -CH=CHC(=O)NH wherein n is 1 or 2, n1 is 2 or 3 and X2 is NH, O or S; and a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof, processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them
Synthesis of rigid dopamine congeners: Naphtho[1,4]oxazine derivatives
Perrone,Berardi,Bettoni,Tortorella
, p. 422 - 428 (2007/10/02)
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