247203-80-1Relevant articles and documents
Synthesis and erythropoietin receptor binding affinities of N, N-disubstituted amino acids
Connolly, Peter J.,Wetter, Steven K.,Murray, William V.,Johnson, Dana L.,McMahon, Frank J.,Farrell, Francis X.,Tullai, Jennifer,Jolliffe, Linda K.
, p. 1995 - 1999 (2007/10/03)
N,N-Dicinnamyl, N-benzyl-N-cinnamyl, and N,N-dibenzyl amino acids were prepared and evaluated in an EPO binding assay. Several derivatives of aspartic acid, glutamic acid, and lysine exhibited moderate (10-50 μM) affinity for EBP; 'dimerization' of the most potent analogues by coupling with linear diamines led to EPO competitors having 1-2 μM binding affinities. (C) 2000 Elsevier Science Ltd.
