247210-89-5

Upstream product

• 247210-69-1 N-diethoxyphosphoryl-N',N''-bis(p-toluenesulfonyl)-3,3'-iminobis[propylamine] 
• 626-15-3 1,3-bis-(bromomethyl)benzene 
• 111-94-4 3,3'-Iminodipropionitrile 
• 90974-12-2 N-diethoxyphosphoryl-3,3'-iminodipropionitrile 
• 247210-68-0 N-diethoxyphosphoryl-3,3'-iminobis[propylamine] 

Downstream Products

• 247210-99-7 C₆₄H₇₆N₆O₈S₄ 
• 247210-96-4 3,11-di(p-tosyl)-3,7,11-triaza-dicyclo[11.3.1]heptadecan-1⁽¹⁶⁾,13⁽¹⁷⁾,14-triene 

Relevant academic research and scientific papers

ARENE CONNECTED POLYAMINE MACRORING DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL USES THEREOF

Abstract: The present invention relates to arene connected polyamine macrocyclic derivatives represented by general formula I, pharmaceutically acceptable salts or hydrates thereof which have anti-HIV activities, in which the definitions of substituents are as defined in the description; to preparation methods of the compounds of formula I; to pharmaceutical compositions containing the compounds of formula I or their pharmaceutically acceptable salts or hydrates; to the use of the compounds of formula I or their pharmaceutically acceptable salts or hydrates for the preparation of a medicament for the treatment and prevention of HIV-associated diseases.

Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-azamacrocycles that inhibit HIV-1 and HIV- 2 replication by antagonism of the chemokine receptor CXCR4

Bis-tetraazamacrocycles such as the bicyclam AMD3100 are a class of potent and selective anti-HIV-1 and HIV-2 agents that inhibit virus replication by binding to the chemokine receptor CXCR4, the co-receptor for entry of X4 viruses. With the aim of optimi