247217-74-9Relevant academic research and scientific papers
Preparation of methylenedifluorocyclopropanes via cyclopropyl anion promoted β-elimination
Shibuya, Akira,Okada, Midori,Nakamura, Yuko,Kibashi, Mie,Horikawa, Hiroaki,Taguchi, Takeo
, p. 10325 - 10340 (2007/10/03)
Preparation of methylenedifluorocyclopropanes 2 through the β- elimination reaction promoted by difluorocyclopropyl anion formed by cleavage of C-Si bond with TBAF is described. Base-catalyzed isomerization of 2 to difluorocyclopropene 11 shows the latter structure thermodynamically more stable in contrast to non-fluorinated cases. Application of this method to the synthesis of methylenedifluorocyclopropylglycine (F2MCPG) derivative 17 is also presented.
