247256-06-0Relevant articles and documents
A new ligand containing a unique combination of backbone- and P-centered chirality: Synthesis, resolution and asymmetric catalysis using a chiral enantiopure 2,2'-biphospholene
Bienewald, Frank,Ricard, Louis,Mercier, Francois,Mathey, Francois
, p. 4701 - 4707 (1999)
Enantiopure 2,2'-bi(1-phenyl-3,4-dimethyl-2,5-dihydro-1H-phosphole) has been synthesized and tested in the rhodium-catalyzed asymmetric hydrogenation of α-acetamidocinnamic acid. Enantioselectivities up to 75% have been achieved. The absolute configuration of the biphospholene was determined by X-ray diffraction methods on a crystalline tungsten carbonyl derivative. (C) 2000 Elsevier Science Ltd.